PRKACB

GENE INFORMATION

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Gene name

PRKACB (HGNC Symbol)

Synonyms

PKACb

Description

Protein kinase, cAMP-dependent, catalytic, beta (HGNC Symbol)

Entrez gene summary

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Several alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jun 2011]

Chromosome

1

Cytoband

p31.1

Chromosome location (bp)

84543745 - 84704181

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000142875 (version 75.37)

Entrez gene

5567

UniProt

P22694 (UniProt - Evidence at protein level)

neXtProt

NX_P22694

Antibodypedia

PRKACB antibodies
 

PROTEIN VIEW

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 « 
 
PRKACB-001
 
PRKACB-002
 
PRKACB-003
 
PRKACB-004
 
PRKACB-005
 
PRKACB-007
 
PRKACB-008
 
PRKACB-009
 
PRKACB-010
 
PRKACB-011
 
PRKACB-012
 
PRKACB-013
 
PRKACB-201
 
PRKACB-202
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRKACB-001 ENSP00000359723
ENST00000370689
P22694
Show all »
Show » Show » 351 40.6 No 0
PRKACB-002 ENSP00000359722
ENST00000370688
P22694
Show all »
Show » Show » 257 29.7 No 0
PRKACB-003 ENSP00000359714
ENST00000370680
B1APG3
Show all »
Show » Show » 264 30.5 No 0
PRKACB-004 ENSP00000359719
ENST00000370685
P22694
Show all »
Show » Show » 398 46.2 No 0
PRKACB-005 ENSP00000378315
ENST00000394839
P22694
Show all »
Show » Show » 321 37 No 0
PRKACB-007 ENSP00000401252
ENST00000446538
B1APF6
Show all »
Show » Show » 175 20.3 No 0
PRKACB-008 ENSP00000359718
ENST00000370684
B1APF9
Show all »
Show » Show » 245 28.5 No 0
PRKACB-009 ENSP00000390906
ENST00000436133
B1APF7
Show all »
Show » Show » 186 21.6 No 0
PRKACB-010 ENSP00000392275
ENST00000432111
B1APF8
Show all »
Show » Show » 214 24.9 No 0
PRKACB-011 ENSP00000393654
ENST00000450730
B1APG0
Show all »
Show » Show » 206 23.9 No 0
PRKACB-012 ENSP00000397175
ENST00000413538
B1APG2
Show all »
Show » Show » 209 24.3 No 0
PRKACB-013 ENSP00000399326
ENST00000417530
B1APG1
Show all »
Show » Show » 197 23.1 No 0
PRKACB-201 ENSP00000359716
ENST00000370682
P22694
Show all »
Show » Show » 355 41 No 0
PRKACB-202 ENSP00000378314
ENST00000394838
P22694
Show all »
Show » Show » 358 41.4 No 0