The Human Protein Atlas

GENE INFORMATION

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Gene name	PRKACB (HGNC Symbol)
Synonyms	PKACb
Description	protein kinase, cAMP-dependent, catalytic, beta (HGNC Symbol)
Entrez gene summary	cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Several alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jun 2011]
Chromosome	1 (Chromosome progress)
Cytoband	p31.1
Chromosome location (bp)	84543745 - 84704181
Ensembl	ENSG00000142875 (version 69.37)
Entrez gene	5567
UniProt	P22694
neXtProt	NX_P22694
Antibodypedia	PRKACB antibodies

PROTEIN VIEW

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PRKACB-001		PRKACB-002		PRKACB-003		PRKACB-004		PRKACB-005		PRKACB-007		PRKACB-008		PRKACB-009		PRKACB-010		PRKACB-011		PRKACB-012		PRKACB-013		PRKACB-201		PRKACB-202		PRKACB-203

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
PRKACB-001	ENSP00000359723 ENST00000370689	P22694 Show all » « Hide P22694 [Direct mapping] cAMP-dependent protein kinase catalytic subunit beta B2RB89 [Target identity:100%; Query identity:100%] Protein kinase, cAMP-dependent, catalytic, beta, isoform CRA_a; cAMP-dependent protein kinase catalytic subunit beta isoform 2; cDNA, FLJ95374, Homo sapiens protein kinase, cAMP-dependent, catalytic, beta(PRKACB), transcript variant 2, mRNA	Show » « Hide Kinases AGC Ser/Thr protein kinases Enzymes Transferases Potential transmembrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000287 [magnesium ion binding] GO:0004691 [cAMP-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005952 [cAMP-dependent protein kinase complex] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006112 [energy reserve metabolic process] GO:0006468 [protein phosphorylation] GO:0006629 [lipid metabolic process] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007188 [G-protein signaling, coupled to cAMP nucleotide second messenger] GO:0007202 [activation of phospholipase C activity] GO:0007243 [intracellular protein kinase cascade] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0019433 [triglyceride catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0044281 [small molecule metabolic process] GO:0048011 [nerve growth factor receptor signaling pathway] GO:0050796 [regulation of insulin secretion] GO:0055085 [transmembrane transport] GO:0071377 [cellular response to glucagon stimulus]	351	40.6	No	0
PRKACB-002	ENSP00000359722 ENST00000370688	P22694 Show all » « Hide P22694 [Direct mapping] cAMP-dependent protein kinase catalytic subunit beta	Show » « Hide Kinases AGC Ser/Thr protein kinases Enzymes Transferases Potential transmembrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000287 [magnesium ion binding] GO:0004691 [cAMP-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005952 [cAMP-dependent protein kinase complex] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006112 [energy reserve metabolic process] GO:0006468 [protein phosphorylation] GO:0006629 [lipid metabolic process] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007188 [G-protein signaling, coupled to cAMP nucleotide second messenger] GO:0007202 [activation of phospholipase C activity] GO:0007243 [intracellular protein kinase cascade] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0019433 [triglyceride catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0044281 [small molecule metabolic process] GO:0048011 [nerve growth factor receptor signaling pathway] GO:0050796 [regulation of insulin secretion] GO:0055085 [transmembrane transport] GO:0071377 [cellular response to glucagon stimulus]	257	29.7	No	0
PRKACB-003	ENSP00000359714 ENST00000370680	B1APG3 Show all » « Hide B1APG3 [Target identity:100%; Query identity:100%] Protein kinase, cAMP-dependent, catalytic, beta; cAMP-dependent protein kinase catalytic subunit beta	Show » « Hide Potential transmembrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins	Show » « Hide GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding]	264	30.5	No	0
PRKACB-004	ENSP00000359719 ENST00000370685	P22694 Show all » « Hide P22694 [Direct mapping] cAMP-dependent protein kinase catalytic subunit beta	Show » « Hide Kinases AGC Ser/Thr protein kinases Enzymes Transferases Potential transmembrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000287 [magnesium ion binding] GO:0004691 [cAMP-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005952 [cAMP-dependent protein kinase complex] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006112 [energy reserve metabolic process] GO:0006468 [protein phosphorylation] GO:0006629 [lipid metabolic process] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007188 [G-protein signaling, coupled to cAMP nucleotide second messenger] GO:0007202 [activation of phospholipase C activity] GO:0007243 [intracellular protein kinase cascade] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0019433 [triglyceride catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0044281 [small molecule metabolic process] GO:0048011 [nerve growth factor receptor signaling pathway] GO:0050796 [regulation of insulin secretion] GO:0055085 [transmembrane transport] GO:0071377 [cellular response to glucagon stimulus]	398	46.2	No	0
PRKACB-005	ENSP00000378315 ENST00000394839	B1APG4 Show all » « Hide B1APG4 [Target identity:100%; Query identity:100%] Protein kinase, cAMP-dependent, catalytic, beta; cAMP-dependent protein kinase catalytic subunit beta; cDNA FLJ34101 fis, clone FCBBF3007631, highly similar to cAMP-dependent protein kinase, beta-catalytic subunit	Show » « Hide Potential transmembrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins	Show » « Hide GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding]	321	37	No	0
PRKACB-007	ENSP00000401252 ENST00000446538	B1APF6 Show all » « Hide B1APF6 [Target identity:100%; Query identity:100%] Protein kinase, cAMP-dependent, catalytic, beta; cAMP-dependent protein kinase catalytic subunit beta		Show » « Hide GO:0004672 [protein kinase activity] GO:0005524 [ATP binding]	175	20.3	No	0
PRKACB-008	ENSP00000359718 ENST00000370684	B1APF9 Show all » « Hide B1APF9 [Target identity:100%; Query identity:100%] Protein kinase, cAMP-dependent, catalytic, beta; cAMP-dependent protein kinase catalytic subunit beta	Show » « Hide Potential transmembrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins	Show » « Hide GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding]	245	28.5	No	0
PRKACB-009	ENSP00000390906 ENST00000436133	B1APF7 Show all » « Hide B1APF7 [Target identity:100%; Query identity:100%] Protein kinase, cAMP-dependent, catalytic, beta; cAMP-dependent protein kinase catalytic subunit beta		Show » « Hide GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding]	186	21.6	No	0
PRKACB-010	ENSP00000392275 ENST00000432111	B1APF8 Show all » « Hide B1APF8 [Target identity:100%; Query identity:100%] Protein kinase, cAMP-dependent, catalytic, beta; cAMP-dependent protein kinase catalytic subunit beta		Show » « Hide GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding]	214	24.9	No	0
PRKACB-011	ENSP00000393654 ENST00000450730	B1APG0 Show all » « Hide B1APG0 [Target identity:100%; Query identity:100%] Protein kinase, cAMP-dependent, catalytic, beta; cAMP-dependent protein kinase catalytic subunit beta		Show » « Hide GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding]	206	23.9	No	0
PRKACB-012	ENSP00000397175 ENST00000413538	B1APG2 Show all » « Hide B1APG2 [Target identity:100%; Query identity:100%] Protein kinase, cAMP-dependent, catalytic, beta; cAMP-dependent protein kinase catalytic subunit beta		Show » « Hide GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding]	209	24.3	No	0
PRKACB-013	ENSP00000399326 ENST00000417530	B1APG1 Show all » « Hide B1APG1 [Target identity:100%; Query identity:100%] Protein kinase, cAMP-dependent, catalytic, beta; cAMP-dependent protein kinase catalytic subunit beta		Show » « Hide GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding]	197	23.1	No	0
PRKACB-201	ENSP00000359713 ENST00000370679	C9JK39 Show all » « Hide C9JK39 [Target identity:100%; Query identity:100%] cAMP-dependent protein kinase catalytic subunit beta	Show » « Hide Potential transmembrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins	Show » « Hide GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding]	357	41.3	No	0
PRKACB-202	ENSP00000359716 ENST00000370682	P22694 Show all » « Hide P22694 [Direct mapping] cAMP-dependent protein kinase catalytic subunit beta B1APF7 [Target identity:52%; Query identity:100%] Protein kinase, cAMP-dependent, catalytic, beta; cAMP-dependent protein kinase catalytic subunit beta	Show » « Hide Kinases AGC Ser/Thr protein kinases Enzymes Transferases Potential transmembrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000287 [magnesium ion binding] GO:0004674 [protein serine/threonine kinase activity] GO:0004691 [cAMP-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005952 [cAMP-dependent protein kinase complex] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006112 [energy reserve metabolic process] GO:0006468 [protein phosphorylation] GO:0006629 [lipid metabolic process] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007188 [G-protein signaling, coupled to cAMP nucleotide second messenger] GO:0007202 [activation of phospholipase C activity] GO:0007243 [intracellular protein kinase cascade] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0019433 [triglyceride catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0044281 [small molecule metabolic process] GO:0048011 [nerve growth factor receptor signaling pathway] GO:0050796 [regulation of insulin secretion] GO:0055085 [transmembrane transport] GO:0071377 [cellular response to glucagon stimulus]	355	41	No	0
PRKACB-203	ENSP00000378314 ENST00000394838	P22694 Show all » « Hide P22694 [Direct mapping] cAMP-dependent protein kinase catalytic subunit beta B1APF6 [Target identity:48%; Query identity:100%] Protein kinase, cAMP-dependent, catalytic, beta; cAMP-dependent protein kinase catalytic subunit beta	Show » « Hide Kinases AGC Ser/Thr protein kinases Enzymes Transferases Potential transmembrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000287 [magnesium ion binding] GO:0004672 [protein kinase activity] GO:0004691 [cAMP-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005952 [cAMP-dependent protein kinase complex] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006112 [energy reserve metabolic process] GO:0006468 [protein phosphorylation] GO:0006629 [lipid metabolic process] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007188 [G-protein signaling, coupled to cAMP nucleotide second messenger] GO:0007202 [activation of phospholipase C activity] GO:0007243 [intracellular protein kinase cascade] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0019433 [triglyceride catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0044281 [small molecule metabolic process] GO:0048011 [nerve growth factor receptor signaling pathway] GO:0050796 [regulation of insulin secretion] GO:0055085 [transmembrane transport] GO:0071377 [cellular response to glucagon stimulus]	358	41.4	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.