AZIN2

GENE INFORMATION

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Gene name

AZIN2 (HGNC Symbol)

Synonyms

ADC, KIAA1945, ODC-p, ODC1L, ODCp

Description

Antizyme inhibitor 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion. Accumulation of antizyme inhibitor 2 has also been observed in brains of patients with Alzheimer's disease. There has been confusion in literature and databases over the nomenclature of this gene, stemming from an earlier report that a human cDNA clone (identical to ODCp/AZIN2) had arginine decarboxylase (ADC) activity (PMID:14738999). Subsequent studies in human and mouse showed that antizyme inhibitor 2 was devoid of arginine decarboxylase activity (PMID:19956990). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]

Chromosome

1

Cytoband

p35.1

Chromosome location (bp)

33081104 - 33120530

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000142920 (version 78.38)

Entrez gene

113451

UniProt

Q96A70 (UniProt - Evidence at protein level)

neXtProt

NX_Q96A70

Antibodypedia

AZIN2 antibodies
 

PROTEIN VIEW

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AZIN2-001
 
AZIN2-002
 
AZIN2-003
 
AZIN2-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AZIN2-001 ENSP00000362542
ENST00000373443
Q96A70
Show all »
Show » Show » 460 50 No 0
AZIN2-002 ENSP00000294517
ENST00000294517
Q96A70
Show all »
Show » Show » 460 50 No 0
AZIN2-003 ENSP00000362540
ENST00000373441
Q96A70
Show all »
Show » Show » 480 51.9 No 0
AZIN2-004 ENSP00000362539
ENST00000373440
Q96A70
Show all »
Show » Show » 204 22.3 No 0