ATP1B1

GENE INFORMATION

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Gene name

ATP1B1 (HGNC Symbol)

Synonyms

ATP1B

Description

ATPase, Na+/K+ transporting, beta 1 polypeptide (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010]

Chromosome

1 (Chromosome progress)

Cytoband

q24.2

Chromosome location (bp)

169074935 - 169101960

Ensembl

ENSG00000143153 (version 73.37)

Entrez gene

481

UniProt

P05026 (UniProt - Evidence at protein level)

neXtProt

NX_P05026

Antibodypedia

ATP1B1 antibodies
 

PROTEIN VIEW

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ATP1B1-001
 
ATP1B1-002
 
ATP1B1-201
 
ATP1B1-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP1B1-001 ENSP00000356789
ENST00000367815
P05026
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Show » Show » 303 35.1 No 1
ATP1B1-002 ENSP00000356790
ENST00000367816
P05026
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Show » Show » 303 35.1 No 1
ATP1B1-201 ENSP00000356787
ENST00000367813
A6NGH2
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Show » Show » 295 34.2 No 1
ATP1B1-202 ENSP00000423450
ENST00000499679
B7Z9S8
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Show » 247 28.6 No 0