PPOX

GENE INFORMATION

? »

Gene name

PPOX (HGNC Symbol)

Synonyms

PPO, VP

Description

protoporphyrinogen oxidase (HGNC Symbol)

Entrez gene summary

This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

q23.3

Chromosome location (bp)

161136200 - 161147803

Ensembl

ENSG00000143224 (version 73.37)

Entrez gene

5498

UniProt

P50336 (UniProt - Evidence at protein level)

neXtProt

NX_P50336

Antibodypedia

PPOX antibodies
 

PROTEIN VIEW

? »
 
 
 
PPOX-001
 
PPOX-002
 
PPOX-010
 
PPOX-011
 
PPOX-012
 
PPOX-018
 
PPOX-020
 
PPOX-201
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PPOX-001 ENSP00000343943
ENST00000352210
P50336
Show all »
Show » Show » 477 50.8 No 0
PPOX-002 ENSP00000356978
ENST00000367999
P50336
Show all »
Show » Show » 477 50.8 No 0
PPOX-010 ENSP00000439613
ENST00000539753
F5H1I5
Show all »
Show » Show » 113 11.8 No 0
PPOX-011 ENSP00000444216
ENST00000544598
F5GZT7
Show all »
Show » Show » 185 19.6 No 0
PPOX-012 ENSP00000443769
ENST00000535223
F5H825
Show all »
156 17.1 Yes 0
PPOX-018 ENSP00000439544
ENST00000537523
Q96SE3
Show all »
Show » 230 24.7 No 0
PPOX-020 ENSP00000438136
ENST00000537829
Show » 161 16.8 No 0
PPOX-201 ENSP00000396841
ENST00000432542
B4DQQ7
Show all »
Show » 238 25.6 Yes 0