F13B

GENE INFORMATION

? »

Gene name

F13B (HGNC Symbol)

Synonyms

FXIIIB

Description

coagulation factor XIII, B polypeptide (HGNC Symbol)

Entrez gene summary

This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

q31.3

Chromosome location (bp)

197008321 - 197036397

Ensembl

ENSG00000143278 (version 73.37)

Entrez gene

2165

UniProt

P05160 (UniProt - Evidence at protein level)

neXtProt

NX_P05160

Antibodypedia

F13B antibodies
 

PROTEIN VIEW

? »
 
 
 
F13B-001
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

F13B-001 ENSP00000356382
ENST00000367412
P05160
Show all »
Show » Show » 661 75.5 Yes 0