CTSK

GENE INFORMATION

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Gene name

CTSK (HGNC Symbol)

Synonyms

CTSO, CTSO2, PKND, PYCD

Description

cathepsin K (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]

Chromosome

1 (Chromosome progress)

Cytoband

q21.3

Chromosome location (bp)

150768684 - 150780799

Ensembl

ENSG00000143387 (version 73.37)

Entrez gene

1513

UniProt

P43235 (UniProt - Evidence at protein level)

neXtProt

NX_P43235

Antibodypedia

CTSK antibodies
 

PROTEIN VIEW

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CTSK-001
 
CTSK-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CTSK-001 ENSP00000271651
ENST00000271651
P43235
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Show » Show » 329 37 Yes 0
CTSK-002 ENSP00000405083
ENST00000443913
Q5QP40
Show all »
Show » Show » 258 29.8 No 1