ENSA

GENE INFORMATION

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Gene name

ENSA (HGNC Symbol)

Synonyms

ARPP-19e, MGC4319, MGC78563, MGC8394

Description

endosulfine alpha (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

q21.3

Chromosome location (bp)

150573327 - 150602088

Ensembl

ENSG00000143420 (version 73.37)

Entrez gene

2029

UniProt

O43768 (UniProt - Evidence at protein level)

neXtProt

NX_O43768

Antibodypedia

ENSA antibodies
 

PROTEIN VIEW

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 « 
 
ENSA-001
 
ENSA-002
 
ENSA-003
 
ENSA-004
 
ENSA-005
 
ENSA-006
 
ENSA-007
 
ENSA-008
 
ENSA-010
 
ENSA-012
 
ENSA-013
 
ENSA-015
 
ENSA-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ENSA-001 ENSP00000358010
ENST00000369014
O43768
Show all »
Show » 121 13.4 No 0
ENSA-002 ENSP00000271690
ENST00000271690
O43768
Show all »
Show » 117 13 No 0
ENSA-003 ENSP00000355220
ENST00000362052
O43768
Show all »
Show » 105 12 No 0
ENSA-004 ENSP00000358012
ENST00000369016
Q5T5H1
Show all »
Show » 187 21 No 0
ENSA-005 ENSP00000355239
ENST00000361631
O43768
Show all »
Show » Show » 133 14.7 No 0
ENSA-006 ENSP00000341743
ENST00000339643
O43768
Show all »
Show » Show » 137 15.3 No 0
ENSA-007 ENSP00000422343
ENST00000513281
O43768
Show all »
Show » 113 12.4 No 0
ENSA-008 ENSP00000354835
ENST00000361532
O43768
Show all »
Show » 117 12.8 No 0
ENSA-010 ENSP00000348921
ENST00000356527
A6NMQ3
Show all »
Show » 140 15.6 No 0
ENSA-012 ENSP00000421458
ENST00000503345
O43768
Show all »
Show » 105 12 No 0
ENSA-013 ENSP00000426110
ENST00000509582
O43768
Show all »
Show » 105 12 No 0
ENSA-015 ENSP00000424242
ENST00000503241
O43768
Show all »
Show » Show » 133 14.9 No 0
ENSA-201 ENSP00000358005
ENST00000369009
C9JUF4
Show all »
Show » 144 16 No 0