ARNT

GENE INFORMATION

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Gene name

ARNT (HGNC Symbol)

Synonyms

bHLHe2, HIF-1beta

Description

aryl hydrocarbon receptor nuclear translocator (HGNC Symbol)

Entrez gene summary

The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1. A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]

Chromosome

1 (Chromosome progress)

Cytoband

q21.3

Chromosome location (bp)

150782181 - 150849244

Ensembl

ENSG00000143437 (version 73.37)

Entrez gene

405

UniProt

P27540 (UniProt - Evidence at protein level)

neXtProt

NX_P27540

Antibodypedia

ARNT antibodies
 

PROTEIN VIEW

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ARNT-001
 
ARNT-006
 
ARNT-007
 
ARNT-009
 
ARNT-010
 
ARNT-012
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ARNT-001 ENSP00000351407
ENST00000358595
P27540
Show all »
Show » Show » 789 86.6 No 0
ARNT-006 ENSP00000423851
ENST00000515192
P27540
Show all »
Show » Show » 775 85.3 No 0
ARNT-007 ENSP00000425899
ENST00000471844
A6NGV6
Show all »
Show » Show » 416 45.9 No 0
ARNT-009 ENSP00000427571
ENST00000505755
P27540
Show all »
Show » Show » 774 84.9 No 0
ARNT-010 ENSP00000346372
ENST00000354396
F8WAP6
Show all »
Show » Show » 787 86.4 No 0
ARNT-012 ENSP00000425363
ENST00000504358
D6RDB3
Show all »
Show » 55 5.4 No 0