KCNH1

GENE INFORMATION

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Gene name

KCNH1 (HGNC Symbol)

Synonyms

eag, eag1, h-eag, Kv10.1

Description

potassium voltage-gated channel, subfamily H (eag-related), member 1 (HGNC Symbol)

Entrez gene summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

q32.2

Chromosome location (bp)

210856555 - 211307457

Ensembl

ENSG00000143473 (version 73.37)

Entrez gene

3756

UniProt

O95259 (UniProt - Evidence at protein level)

neXtProt

NX_O95259

Antibodypedia

KCNH1 antibodies
 

PROTEIN VIEW

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KCNH1-001
 
KCNH1-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCNH1-001 ENSP00000271751
ENST00000271751
O95259
Show all »
Show » Show » 989 111.4 No 5
KCNH1-002 ENSP00000355974
ENST00000367007
O95259
Show all »
Show » Show » 962 108.6 No 6