ADAM15

GENE INFORMATION

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Gene name

ADAM15 (HGNC Symbol)

Synonyms

MDC15

Description

ADAM metallopeptidase domain 15 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

q22

Chromosome location (bp)

155023042 - 155035252

Ensembl

ENSG00000143537 (version 73.37)

Entrez gene

8751

UniProt

Q13444 (UniProt - Evidence at protein level)

neXtProt

NX_Q13444

Antibodypedia

ADAM15 antibodies
 

PROTEIN VIEW

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 « 
 
ADAM15-001
 
ADAM15-002
 
ADAM15-019
 
ADAM15-020
 
ADAM15-021
 
ADAM15-022
 
ADAM15-023
 
ADAM15-024
 
ADAM15-025
 
ADAM15-026
 
ADAM15-027
 
ADAM15-037
 
ADAM15-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAM15-001 ENSP00000271836
ENST00000271836
Q13444
Show all »
Show » Show » 814 87.7 Yes 1
ADAM15-002 ENSP00000357398
ENST00000368413
Q13444
Show all »
Show » Show » 520 55.4 Yes 1
ADAM15-019 ENSP00000349436
ENST00000356955
Q13444
Show all »
Show » Show » 863 93 Yes 1
ADAM15-020 ENSP00000403843
ENST00000449910
Q13444
Show all »
Show » Show » 862 92.8 Yes 1
ADAM15-021 ENSP00000432347
ENST00000526491
Q13444
Show all »
Show » Show » 822 88.8 Yes 1
ADAM15-022 ENSP00000434227
ENST00000529473
Q13444
Show all »
Show » Show » 797 86.1 Yes 1
ADAM15-023 ENSP00000352226
ENST00000359280
Q13444
Show all »
Show » Show » 838 90.3 Yes 1
ADAM15-024 ENSP00000353892
ENST00000360674
Q13444
Show all »
Show » Show » 772 83.7 Yes 1
ADAM15-025 ENSP00000357397
ENST00000368412
Q13444
Show all »
Show » Show » 796 86.3 Yes 1
ADAM15-026 ENSP00000432927
ENST00000531455
Q13444
Show all »
Show » Show » 824 88.7 Yes 1
ADAM15-027 ENSP00000476000
ENST00000447332
Show » 633 68.3 Yes 0
ADAM15-037 ENSP00000348227
ENST00000355956
Q13444
Show all »
Show » Show » 839 90.4 Yes 1
ADAM15-201 ENSP00000357395
ENST00000368410
A6NG98
Show all »
Show » Show » 520 55.5 Yes 1