KCNN3

GENE INFORMATION

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Gene name

KCNN3 (HGNC Symbol)

Synonyms

hSK3, KCa2.3, SKCA3

Description

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 (HGNC Symbol)

Entrez gene summary

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Chromosome

1 (Chromosome progress)

Cytoband

q21.3

Chromosome location (bp)

154675205 - 154842756

Ensembl

ENSG00000143603 (version 73.37)

Entrez gene

3782

UniProt

Q9UGI6 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9UGI6

Antibodypedia

KCNN3 antibodies
 

PROTEIN VIEW

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KCNN3-001
 
KCNN3-002
 
KCNN3-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCNN3-001 ENSP00000271915
ENST00000271915
Q9UGI6
Show all »
Show » Show » 731 81.4 No 7
KCNN3-002 ENSP00000354764
ENST00000361147
Q9UGI6
Show all »
Show » Show » 426 48.1 No 5
KCNN3-003 ENSP00000351295
ENST00000358505
Q86VF9
Show all »
Show » Show » 418 47.1 No 4