DEGS1

GENE INFORMATION

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Gene name

DEGS1 (HGNC Symbol)

Synonyms

DEGS-1, Des-1, DES1, FADS7, MLD

Description

delta(4)-desaturase, sphingolipid 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor. [provided by RefSeq, Mar 2010]

Chromosome

1 (Chromosome progress)

Cytoband

q42.11

Chromosome location (bp)

224363458 - 224381143

Ensembl

ENSG00000143753 (version 73.37)

Entrez gene

8560

UniProt

O15121 (UniProt - Evidence at protein level)

neXtProt

NX_O15121

Antibodypedia

DEGS1 antibodies
 

PROTEIN VIEW

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DEGS1-001
 
DEGS1-004
 
DEGS1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DEGS1-001 ENSP00000316476
ENST00000323699
O15121
Show all »
Show » Show » 323 37.9 No 4
DEGS1-004 ENSP00000400545
ENST00000415210
E7EMA0
Show all »
Show » Show » 261 30.1 No 5
DEGS1-201 ENSP00000375749
ENST00000391877
O15121
Show all »
Show » Show » 323 37.9 No 4