REN

GENE INFORMATION

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Gene name

REN

Synonyms

Description

renin (HGNC Symbol)

Entrez gene summary

Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

q32.1

Chromosome location (bp)

204123944 - 204135465

Ensembl

ENSG00000143839 (version 73.37)

Entrez gene

5972

UniProt

P00797 (UniProt - Evidence at protein level)

neXtProt

NX_P00797

Antibodypedia

REN antibodies
 

PROTEIN VIEW

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REN-001
 
REN-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

REN-001 ENSP00000272190
ENST00000272190
P00797
Show all »
Show » Show » 406 45.1 Yes 0
REN-201 ENSP00000356163
ENST00000367195
P00797
Show all »
Show » Show » 403 44.7 Yes 0