ATP6V1C2

GENE INFORMATION

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Gene name

ATP6V1C2 (HGNC Symbol)

Synonyms

ATP6C2, VMA5

Description

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 (HGNC Symbol)

Entrez gene summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A,three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain C subunit isoforms. [provided by RefSeq, Jul 2008]

Chromosome

2 (Chromosome progress)

Cytoband

p25.1

Chromosome location (bp)

10861775 - 10925236

Ensembl

ENSG00000143882 (version 73.37)

Entrez gene

245973

UniProt

Q8NEY4 (UniProt - Evidence at transcript level)

neXtProt

NX_Q8NEY4

Antibodypedia

ATP6V1C2 antibodies
 

PROTEIN VIEW

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ATP6V1C2-001
 
ATP6V1C2-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP6V1C2-001 ENSP00000371077
ENST00000381661
Q8NEY4
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Show » Show » 381 43.9 No 0
ATP6V1C2-002 ENSP00000272238
ENST00000272238
Q8NEY4
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Show » Show » 427 48.8 No 0