RPS27A

GENERAL INFORMATION

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Gene name

RPS27A

Gene description

Ribosomal protein S27a

Protein class

Predicted intracellular proteins
Ribosomal proteins

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Nuclear expression in all tissues with cytoplasmic expression in some.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation. Caution, targets protein from more than one gene.

Data reliability

Supportive based on 3 antibodies.
HPA041344 , HPA049132 , CAB033319
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

RPS27A (HGNC Symbol)

Synonyms

S27A, Uba80, UBCEP80

Description

Ribosomal protein S27a (HGNC Symbol)

Entrez gene summary

Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi. Multiple alternatively spliced transcript variants that encode the same proteins have been identified.[provided by RefSeq, Sep 2008]

Chromosome

2

Cytoband

p16.1

Chromosome location (bp)

55231903 - 55235853

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000143947 (version 78.38)

Entrez gene

6233

UniProt

P62979 (UniProt - Evidence at protein level)

neXtProt

NX_P62979

Antibodypedia

RPS27A antibodies


PROTEIN BROWSER

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ENST00000272317
 
ENST00000402285
 
ENST00000404735
 
ENST00000449323
 
ENST00000611893
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RPS27A-001 ENSP00000272317
ENST00000272317
P62979
Show all »
Show » Show » 156 18 No 0
RPS27A-002 ENSP00000385659
ENST00000404735
P62979
Show all »
Show » Show » 156 18 No 0
RPS27A-003 ENSP00000383981
ENST00000402285
P62979
Show all »
Show » Show » 156 18 No 0
RPS27A-004 ENSP00000408482
ENST00000449323
J3QTR3
Show all »
Show » Show » 106 12.2 No 0
RPS27A-201 ENSP00000479245
ENST00000611893
Q49A90
Show all »
Show » Show » 66 7.4 No 0