ACKR2

GENE INFORMATION

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Gene name

ACKR2 (HGNC Symbol)

Synonyms

CCBP2, CCR10, CCR9, CMKBR9, D6

Description

atypical chemokine receptor 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]

Chromosome

3 (Chromosome progress)

Cytoband

p22.1

Chromosome location (bp)

42846244 - 42949597

Ensembl

ENSG00000144648 (version 73.37)

Entrez gene

1238

UniProt

O00590 (UniProt - Evidence at transcript level)

neXtProt

NX_O00590

Antibodypedia

ACKR2 antibodies
 

PROTEIN VIEW

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ACKR2-001
 
ACKR2-003
 
ACKR2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACKR2-001 ENSP00000416996
ENST00000422265
O00590
Show all »
Show » Show » 384 43.4 No 7
ACKR2-003 ENSP00000396150
ENST00000442925
O00590
Show all »
Show » Show » 384 43.4 No 7
ACKR2-201 ENSP00000273145
ENST00000273145
O00590
Show all »
Show » Show » 384 43.4 No 7