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GENE INFORMATION
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The gene information section lists the gene name (HUGO Gene Nomenclature Committee ( HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version. The Entrez gene identifier for the gene is also given. If any of the protein products of the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the neXtProt databases for these proteins are displayed.
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Gene name |
AGTR1 (HGNC Symbol) |
Synonyms |
AG2S, AGTR1A, AGTR1B, AT1, AT1B, AT2R1, AT2R1A, AT2R1B, HAT1R |
Description |
angiotensin II receptor, type 1 (HGNC Symbol) |
Entrez gene summary |
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012] |
Chromosome |
3 (Chromosome progress)
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Cytoband |
q24 |
Chromosome location (bp) |
148415571 - 148460795 |
Ensembl |
ENSG00000144891 (version 69.37) |
Entrez gene |
185 |
UniProt |
P30556 |
neXtProt |
NX_P30556 |
Antibodypedia |
AGTR1 antibodies |
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PROTEIN VIEW
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The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green.
Common (purple) and unique (grey) regions between alternative processed transcripts from the same gene are also displayed ( read more), and at the bottom of the protein view is the protein scale.
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PROTEIN INFORMATION
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The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website for that protein, and the ENST identifier links to the Ensembl website for that transcript. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues) (according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius and predicted transmembrane region(s) (according to MDM) are also reported.
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Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length
(aa) |
Molecular mass
(kDa) |
Signal peptide
(predicted) |
Transmembrane regions
(predicted)
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| AGTR1-001 |
ENSP00000273430
ENST00000349243
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P30556
Show all »
« Hide
P30556 [Direct mapping]Type-1 angiotensin II receptor Q53YY0 [Target identity:100%; Query identity:100%]Angiotensin II receptor, type 1; Angiotensin II receptor, type 1, isoform CRA_b; cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA D3DNG8 [Target identity:100%; Query identity:91%]Angiotensin II receptor, type 1, isoform CRA_a
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Transporters
G-protein coupled receptors
GPCRs excl olfactory receptors
Potential transmembrane proteins
Membrane proteins predicted by MDM
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
Phobius predicted membrane proteins
SCAMPI predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
GPCRHMM predicted membrane proteins
7TM proteins predicted by MDM
Mapped to UniProt SWISS-PROT
UniProt - Evidence at protein level
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Show »
« Hide
GO:0001558 [regulation of cell growth] GO:0001596 [angiotensin type I receptor activity] GO:0001822 [kidney development] GO:0002018 [renin-angiotensin regulation of aldosterone production] GO:0002034 [regulation of blood vessel size by renin-angiotensin] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [elevation of cytosolic calcium ion concentration] GO:0007266 [Rho protein signal transduction] GO:0010698 [acetyltransferase activator activity] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010873 [positive regulation of cholesterol esterification] GO:0016021 [integral to membrane] GO:0019229 [regulation of vasoconstriction] GO:0019722 [calcium-mediated signaling] GO:0031711 [bradykinin receptor binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032430 [positive regulation of phospholipase A2 activity] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034374 [low-density lipoprotein particle remodeling] GO:0035813 [regulation of renal sodium excretion] GO:0042127 [regulation of cell proliferation] GO:0042312 [regulation of vasodilation] GO:0046982 [protein heterodimerization activity] GO:0050727 [regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0051482 [elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0060326 [cell chemotaxis] GO:0086097 [phospholipase C-activating angiotensin-mediated signaling pathway] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
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359 |
41.1 |
No |
7 |
| AGTR1-002 |
ENSP00000419422
ENST00000497524
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P30556
Show all »
« Hide
P30556 [Direct mapping]Type-1 angiotensin II receptor Q53YY0 [Target identity:100%; Query identity:100%]Angiotensin II receptor, type 1; Angiotensin II receptor, type 1, isoform CRA_b; cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA D3DNG8 [Target identity:100%; Query identity:91%]Angiotensin II receptor, type 1, isoform CRA_a
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Show »
« Hide
Transporters
G-protein coupled receptors
GPCRs excl olfactory receptors
Potential transmembrane proteins
Membrane proteins predicted by MDM
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
Phobius predicted membrane proteins
SCAMPI predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
GPCRHMM predicted membrane proteins
7TM proteins predicted by MDM
Mapped to UniProt SWISS-PROT
UniProt - Evidence at protein level
|
Show »
« Hide
GO:0001558 [regulation of cell growth] GO:0001596 [angiotensin type I receptor activity] GO:0001822 [kidney development] GO:0002018 [renin-angiotensin regulation of aldosterone production] GO:0002034 [regulation of blood vessel size by renin-angiotensin] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [elevation of cytosolic calcium ion concentration] GO:0007266 [Rho protein signal transduction] GO:0010698 [acetyltransferase activator activity] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010873 [positive regulation of cholesterol esterification] GO:0016021 [integral to membrane] GO:0019229 [regulation of vasoconstriction] GO:0019722 [calcium-mediated signaling] GO:0031711 [bradykinin receptor binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032430 [positive regulation of phospholipase A2 activity] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034374 [low-density lipoprotein particle remodeling] GO:0035813 [regulation of renal sodium excretion] GO:0042127 [regulation of cell proliferation] GO:0042312 [regulation of vasodilation] GO:0046982 [protein heterodimerization activity] GO:0050727 [regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0051482 [elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0060326 [cell chemotaxis] GO:0086097 [phospholipase C-activating angiotensin-mediated signaling pathway] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
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359 |
41.1 |
No |
7 |
| AGTR1-003 |
ENSP00000385612
ENST00000404754
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P30556
Show all »
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P30556 [Direct mapping]Type-1 angiotensin II receptor Q53YY0 [Target identity:100%; Query identity:100%]Angiotensin II receptor, type 1; Angiotensin II receptor, type 1, isoform CRA_b; cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA D3DNG8 [Target identity:100%; Query identity:91%]Angiotensin II receptor, type 1, isoform CRA_a
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Show »
« Hide
Transporters
G-protein coupled receptors
GPCRs excl olfactory receptors
Potential transmembrane proteins
Membrane proteins predicted by MDM
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
Phobius predicted membrane proteins
SCAMPI predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
GPCRHMM predicted membrane proteins
7TM proteins predicted by MDM
Mapped to UniProt SWISS-PROT
UniProt - Evidence at protein level
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Show »
« Hide
GO:0001558 [regulation of cell growth] GO:0001596 [angiotensin type I receptor activity] GO:0001822 [kidney development] GO:0002018 [renin-angiotensin regulation of aldosterone production] GO:0002034 [regulation of blood vessel size by renin-angiotensin] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [elevation of cytosolic calcium ion concentration] GO:0007266 [Rho protein signal transduction] GO:0010698 [acetyltransferase activator activity] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010873 [positive regulation of cholesterol esterification] GO:0016021 [integral to membrane] GO:0019229 [regulation of vasoconstriction] GO:0019722 [calcium-mediated signaling] GO:0031711 [bradykinin receptor binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032430 [positive regulation of phospholipase A2 activity] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034374 [low-density lipoprotein particle remodeling] GO:0035813 [regulation of renal sodium excretion] GO:0042127 [regulation of cell proliferation] GO:0042312 [regulation of vasodilation] GO:0046982 [protein heterodimerization activity] GO:0050727 [regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0051482 [elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0060326 [cell chemotaxis] GO:0086097 [phospholipase C-activating angiotensin-mediated signaling pathway] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
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359 |
41.1 |
No |
7 |
| AGTR1-005 |
ENSP00000419783
ENST00000475347
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P30556
Show all »
« Hide
P30556 [Direct mapping]Type-1 angiotensin II receptor Q53YY0 [Target identity:100%; Query identity:100%]Angiotensin II receptor, type 1; Angiotensin II receptor, type 1, isoform CRA_b; cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA D3DNG8 [Target identity:100%; Query identity:91%]Angiotensin II receptor, type 1, isoform CRA_a
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Show »
« Hide
Transporters
G-protein coupled receptors
GPCRs excl olfactory receptors
Potential transmembrane proteins
Membrane proteins predicted by MDM
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
Phobius predicted membrane proteins
SCAMPI predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
GPCRHMM predicted membrane proteins
7TM proteins predicted by MDM
Mapped to UniProt SWISS-PROT
UniProt - Evidence at protein level
|
Show »
« Hide
GO:0001558 [regulation of cell growth] GO:0001596 [angiotensin type I receptor activity] GO:0001822 [kidney development] GO:0002018 [renin-angiotensin regulation of aldosterone production] GO:0002034 [regulation of blood vessel size by renin-angiotensin] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [elevation of cytosolic calcium ion concentration] GO:0007266 [Rho protein signal transduction] GO:0010698 [acetyltransferase activator activity] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010873 [positive regulation of cholesterol esterification] GO:0016021 [integral to membrane] GO:0019229 [regulation of vasoconstriction] GO:0019722 [calcium-mediated signaling] GO:0031711 [bradykinin receptor binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032430 [positive regulation of phospholipase A2 activity] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034374 [low-density lipoprotein particle remodeling] GO:0035813 [regulation of renal sodium excretion] GO:0042127 [regulation of cell proliferation] GO:0042312 [regulation of vasodilation] GO:0046982 [protein heterodimerization activity] GO:0050727 [regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0051482 [elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0060326 [cell chemotaxis] GO:0086097 [phospholipase C-activating angiotensin-mediated signaling pathway] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
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359 |
41.1 |
No |
7 |
| AGTR1-006 |
ENSP00000418084
ENST00000474935
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P30556
Show all »
« Hide
P30556 [Direct mapping]Type-1 angiotensin II receptor Q53YY0 [Target identity:100%; Query identity:100%]Angiotensin II receptor, type 1; Angiotensin II receptor, type 1, isoform CRA_b; cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA D3DNG8 [Target identity:100%; Query identity:91%]Angiotensin II receptor, type 1, isoform CRA_a
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Show »
« Hide
Transporters
G-protein coupled receptors
GPCRs excl olfactory receptors
Potential transmembrane proteins
Membrane proteins predicted by MDM
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
Phobius predicted membrane proteins
SCAMPI predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
GPCRHMM predicted membrane proteins
7TM proteins predicted by MDM
Mapped to UniProt SWISS-PROT
UniProt - Evidence at protein level
|
Show »
« Hide
GO:0001558 [regulation of cell growth] GO:0001596 [angiotensin type I receptor activity] GO:0001822 [kidney development] GO:0002018 [renin-angiotensin regulation of aldosterone production] GO:0002034 [regulation of blood vessel size by renin-angiotensin] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [elevation of cytosolic calcium ion concentration] GO:0007266 [Rho protein signal transduction] GO:0010698 [acetyltransferase activator activity] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010873 [positive regulation of cholesterol esterification] GO:0016021 [integral to membrane] GO:0019229 [regulation of vasoconstriction] GO:0019722 [calcium-mediated signaling] GO:0031711 [bradykinin receptor binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032430 [positive regulation of phospholipase A2 activity] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034374 [low-density lipoprotein particle remodeling] GO:0035813 [regulation of renal sodium excretion] GO:0042127 [regulation of cell proliferation] GO:0042312 [regulation of vasodilation] GO:0046982 [protein heterodimerization activity] GO:0050727 [regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0051482 [elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0060326 [cell chemotaxis] GO:0086097 [phospholipase C-activating angiotensin-mediated signaling pathway] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
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359 |
41.1 |
No |
7 |
| AGTR1-007 |
ENSP00000418851
ENST00000461609
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P30556
Show all »
« Hide
P30556 [Direct mapping]Type-1 angiotensin II receptor Q53YY0 [Target identity:100%; Query identity:100%]Angiotensin II receptor, type 1; Angiotensin II receptor, type 1, isoform CRA_b; cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA D3DNG8 [Target identity:100%; Query identity:91%]Angiotensin II receptor, type 1, isoform CRA_a
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Show »
« Hide
Transporters
G-protein coupled receptors
GPCRs excl olfactory receptors
Potential transmembrane proteins
Membrane proteins predicted by MDM
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
Phobius predicted membrane proteins
SCAMPI predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
GPCRHMM predicted membrane proteins
7TM proteins predicted by MDM
Mapped to UniProt SWISS-PROT
UniProt - Evidence at protein level
|
Show »
« Hide
GO:0001558 [regulation of cell growth] GO:0001596 [angiotensin type I receptor activity] GO:0001822 [kidney development] GO:0002018 [renin-angiotensin regulation of aldosterone production] GO:0002034 [regulation of blood vessel size by renin-angiotensin] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [elevation of cytosolic calcium ion concentration] GO:0007266 [Rho protein signal transduction] GO:0010698 [acetyltransferase activator activity] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010873 [positive regulation of cholesterol esterification] GO:0016021 [integral to membrane] GO:0019229 [regulation of vasoconstriction] GO:0019722 [calcium-mediated signaling] GO:0031711 [bradykinin receptor binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032430 [positive regulation of phospholipase A2 activity] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034374 [low-density lipoprotein particle remodeling] GO:0035813 [regulation of renal sodium excretion] GO:0042127 [regulation of cell proliferation] GO:0042312 [regulation of vasodilation] GO:0046982 [protein heterodimerization activity] GO:0050727 [regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0051482 [elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0060326 [cell chemotaxis] GO:0086097 [phospholipase C-activating angiotensin-mediated signaling pathway] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
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359 |
41.1 |
No |
7 |
| AGTR1-201 |
ENSP00000385641
ENST00000402260
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P30556
Show all »
« Hide
P30556 [Direct mapping]Type-1 angiotensin II receptor Q53YY0 [Target identity:100%; Query identity:100%]Angiotensin II receptor, type 1; Angiotensin II receptor, type 1, isoform CRA_b; cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA D3DNG8 [Target identity:100%; Query identity:91%]Angiotensin II receptor, type 1, isoform CRA_a
|
Show »
« Hide
Transporters
G-protein coupled receptors
GPCRs excl olfactory receptors
Potential transmembrane proteins
Membrane proteins predicted by MDM
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
Phobius predicted membrane proteins
SCAMPI predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
GPCRHMM predicted membrane proteins
7TM proteins predicted by MDM
Mapped to UniProt SWISS-PROT
UniProt - Evidence at protein level
|
Show »
« Hide
GO:0001558 [regulation of cell growth] GO:0001596 [angiotensin type I receptor activity] GO:0001822 [kidney development] GO:0002018 [renin-angiotensin regulation of aldosterone production] GO:0002034 [regulation of blood vessel size by renin-angiotensin] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [elevation of cytosolic calcium ion concentration] GO:0007266 [Rho protein signal transduction] GO:0010698 [acetyltransferase activator activity] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010873 [positive regulation of cholesterol esterification] GO:0016021 [integral to membrane] GO:0019229 [regulation of vasoconstriction] GO:0019722 [calcium-mediated signaling] GO:0031711 [bradykinin receptor binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032430 [positive regulation of phospholipase A2 activity] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034374 [low-density lipoprotein particle remodeling] GO:0035813 [regulation of renal sodium excretion] GO:0042127 [regulation of cell proliferation] GO:0042312 [regulation of vasodilation] GO:0046982 [protein heterodimerization activity] GO:0050727 [regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0051482 [elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0060326 [cell chemotaxis] GO:0086097 [phospholipase C-activating angiotensin-mediated signaling pathway] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
|
359 |
41.1 |
No |
7 |
| AGTR1-202 |
ENSP00000398832
ENST00000418473
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P30556
Show all »
« Hide
P30556 [Direct mapping]Type-1 angiotensin II receptor Q53YY0 [Target identity:100%; Query identity:100%]Angiotensin II receptor, type 1; Angiotensin II receptor, type 1, isoform CRA_b; cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA D3DNG8 [Target identity:100%; Query identity:91%]Angiotensin II receptor, type 1, isoform CRA_a
|
Show »
« Hide
Transporters
G-protein coupled receptors
GPCRs excl olfactory receptors
Potential transmembrane proteins
Membrane proteins predicted by MDM
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
Phobius predicted membrane proteins
SCAMPI predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
GPCRHMM predicted membrane proteins
7TM proteins predicted by MDM
Mapped to UniProt SWISS-PROT
UniProt - Evidence at protein level
|
Show »
« Hide
GO:0001558 [regulation of cell growth] GO:0001596 [angiotensin type I receptor activity] GO:0001822 [kidney development] GO:0002018 [renin-angiotensin regulation of aldosterone production] GO:0002034 [regulation of blood vessel size by renin-angiotensin] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [elevation of cytosolic calcium ion concentration] GO:0007266 [Rho protein signal transduction] GO:0010698 [acetyltransferase activator activity] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010873 [positive regulation of cholesterol esterification] GO:0016021 [integral to membrane] GO:0019229 [regulation of vasoconstriction] GO:0019722 [calcium-mediated signaling] GO:0031711 [bradykinin receptor binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032430 [positive regulation of phospholipase A2 activity] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034374 [low-density lipoprotein particle remodeling] GO:0035813 [regulation of renal sodium excretion] GO:0042127 [regulation of cell proliferation] GO:0042312 [regulation of vasodilation] GO:0046982 [protein heterodimerization activity] GO:0050727 [regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0051482 [elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0060326 [cell chemotaxis] GO:0086097 [phospholipase C-activating angiotensin-mediated signaling pathway] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
|
359 |
41.1 |
No |
7 |
| AGTR1-203 |
ENSP00000443186
ENST00000542281
|
P30556
Show all »
« Hide
P30556 [Direct mapping]Type-1 angiotensin II receptor Q53YY0 [Target identity:100%; Query identity:100%]Angiotensin II receptor, type 1; Angiotensin II receptor, type 1, isoform CRA_b; cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA D3DNG8 [Target identity:100%; Query identity:91%]Angiotensin II receptor, type 1, isoform CRA_a
|
Show »
« Hide
Transporters
G-protein coupled receptors
GPCRs excl olfactory receptors
Potential transmembrane proteins
Membrane proteins predicted by MDM
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
Phobius predicted membrane proteins
SCAMPI predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
GPCRHMM predicted membrane proteins
7TM proteins predicted by MDM
Mapped to UniProt SWISS-PROT
UniProt - Evidence at protein level
|
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GO:0001558 [regulation of cell growth] GO:0001596 [angiotensin type I receptor activity] GO:0001822 [kidney development] GO:0002018 [renin-angiotensin regulation of aldosterone production] GO:0002034 [regulation of blood vessel size by renin-angiotensin] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [elevation of cytosolic calcium ion concentration] GO:0007266 [Rho protein signal transduction] GO:0010698 [acetyltransferase activator activity] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010873 [positive regulation of cholesterol esterification] GO:0016021 [integral to membrane] GO:0019229 [regulation of vasoconstriction] GO:0019722 [calcium-mediated signaling] GO:0031711 [bradykinin receptor binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032430 [positive regulation of phospholipase A2 activity] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034374 [low-density lipoprotein particle remodeling] GO:0035813 [regulation of renal sodium excretion] GO:0042127 [regulation of cell proliferation] GO:0042312 [regulation of vasodilation] GO:0046982 [protein heterodimerization activity] GO:0050727 [regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0051482 [elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0060326 [cell chemotaxis] GO:0086097 [phospholipase C-activating angiotensin-mediated signaling pathway] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
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359 |
41.1 |
No |
7 |
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