ECE2

GENE INFORMATION

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Gene name

ECE2 (HGNC Symbol)

Synonyms

KIAA0604, MGC2408

Description

endothelin converting enzyme 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the M13 family, which includes type 2 integral membrane metallopeptidases. The encoded enzyme is a membrane-bound zinc-dependent metalloprotease. The enzyme catalyzes the cleavage of big endothelin to produce the vasoconstrictor endothelin-1, and plays a role in the processing of several neuroendocrine peptides. It may also have methyltransferase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Chromosome

3 (Chromosome progress)

Cytoband

q27.1

Chromosome location (bp)

183967438 - 184010819

Ensembl

ENSG00000145194 (version 73.37)

Entrez gene

9718

UniProt

O60344 (UniProt - Evidence at protein level)

neXtProt

NX_O60344

Antibodypedia

ECE2 antibodies
 

PROTEIN VIEW

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ECE2-001
 
ECE2-002
 
ECE2-003
 
ECE2-004
 
ECE2-006
 
ECE2-007
 
ECE2-009
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ECE2-001 ENSP00000384223
ENST00000402825
O60344
Show all »
Show » Show » 883 99.8 No 1
ECE2-002 ENSP00000314295
ENST00000324557
O60344
Show all »
Show » Show » 255 28.3 No 0
ECE2-003 ENSP00000385846
ENST00000404464
O60344
Show all »
Show » Show » 765 86.5 No 1
ECE2-004 ENSP00000352052
ENST00000359140
O60344
Show all »
Show » Show » 736 83.3 No 1
ECE2-006 ENSP00000350066
ENST00000357474
O60344
Show all »
Show » Show » 811 91.2 No 1
ECE2-007 ENSP00000398444
ENST00000430587
H0Y5G8
Show all »
Show » Show » 716 81 No 1
ECE2-009 ENSP00000392467
ENST00000422932
F8WCL9
Show all »
Show » Show » 67 7.1 No 0