SNCA

GENE INFORMATION

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Gene name

SNCA (HGNC Symbol)

Synonyms

alpha-synuclein, NACP, PARK1, PARK4, PD1

Description

synuclein, alpha (non A4 component of amyloid precursor) (HGNC Symbol)

Entrez gene summary

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]

Chromosome

4 (Chromosome progress)

Cytoband

q22.1

Chromosome location (bp)

90645250 - 90759466

Ensembl

ENSG00000145335 (version 73.37)

Entrez gene

6622

UniProt

P37840 (UniProt - Evidence at protein level)

neXtProt

NX_P37840

Antibodypedia

SNCA antibodies
 

PROTEIN VIEW

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 « 
 
SNCA-001
 
SNCA-002
 
SNCA-003
 
SNCA-004
 
SNCA-005
 
SNCA-006
 
SNCA-007
 
SNCA-008
 
SNCA-009
 
SNCA-201
 
SNCA-202
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SNCA-001 ENSP00000378437
ENST00000394986
P37840
Show all »
Show » Show » 140 14.5 No 0
SNCA-002 ENSP00000378442
ENST00000394991
P37840
Show all »
Show » Show » 140 14.5 No 0
SNCA-003 ENSP00000338345
ENST00000336904
P37840
Show all »
Show » Show » 140 14.5 No 0
SNCA-004 ENSP00000421485
ENST00000505199
P37840
Show all »
Show » Show » 126 13.1 No 0
SNCA-005 ENSP00000343683
ENST00000345009
P37840
Show all »
Show » Show » 112 11.4 No 0
SNCA-006 ENSP00000422238
ENST00000506244
P37840
Show all »
Show » Show » 140 14.5 No 0
SNCA-007 ENSP00000423445
ENST00000506691
D6RA31
Show all »
Show » 67 6.9 No 0
SNCA-008 ENSP00000426955
ENST00000508895
P37840
Show all »
Show » Show » 140 14.5 No 0
SNCA-009 ENSP00000426034
ENST00000502987
E7EPV7
Show all »
Show » 115 11.8 No 0
SNCA-201 ENSP00000378440
ENST00000394989
P37840
Show all »
Show » Show » 126 13.1 No 0
SNCA-202 ENSP00000396241
ENST00000420646
P37840
Show all »
Show » Show » 112 11.4 No 0