ANK2

GENE INFORMATION

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Gene name

ANK2 (HGNC Symbol)

Synonyms

LQT4

Description

ankyrin 2, neuronal (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2011]

Chromosome

4 (Chromosome progress)

Cytoband

q25

Chromosome location (bp)

113739265 - 114304896

Ensembl

ENSG00000145362 (version 73.37)

Entrez gene

287

UniProt

Q01484 (UniProt - Evidence at protein level)

neXtProt

NX_Q01484

Antibodypedia

ANK2 antibodies
 

PROTEIN VIEW

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 « 
 
ANK2-001
 
ANK2-002
 
ANK2-004
 
ANK2-005
 
ANK2-006
 
ANK2-007
 
ANK2-008
 
ANK2-009
 
ANK2-010
 
ANK2-011
 
ANK2-013
 
ANK2-014
 
ANK2-015
 
ANK2-022
 
ANK2-023
 
ANK2-024
 
ANK2-026
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ANK2-001 ENSP00000349588
ENST00000357077
Q01484
Show all »
Show » Show » 3957 433.7 No 0
ANK2-002 ENSP00000378044
ENST00000394537
Q01484
Show all »
Show » Show » 1872 205.8 No 0
ANK2-004 ENSP00000421067
ENST00000506722
Q01484
Show all »
Show » Show » 1863 204.8 No 0
ANK2-005 ENSP00000424722
ENST00000504454
E9PHW9
Show all »
Show » 1730 189.1 No 0
ANK2-006 ENSP00000426944
ENST00000509550
E9PCH6
Show all »
Show » 1048 117.8 No 0
ANK2-007 ENSP00000422853
ENST00000514960
Show » 966 108.6 No 0
ANK2-008 ENSP00000421023
ENST00000510275
Q01484
Show all »
Show » Show » 555 63.4 No 0
ANK2-009 ENSP00000423799
ENST00000503271
B7Z651
Show all »
Show » 1114 119.9 No 0
ANK2-010 ENSP00000421011
ENST00000503423
D6RHE1
Show all »
Show » 1611 176.1 No 0
ANK2-011 ENSP00000422498
ENST00000505342
H0Y8Y2
Show all »
Show » 1028 114.7 No 0
ANK2-013 ENSP00000422900
ENST00000508613
D6R9U4
Show all »
Show » 177 19.3 No 0
ANK2-014 ENSP00000425775
ENST00000511380
D6RIY9
Show all »
Show » 112 11.9 No 0
ANK2-015 ENSP00000421059
ENST00000515034
D6RHC5
Show all »
Show » 65 6.9 No 0
ANK2-022 ENSP00000426994
ENST00000504415
Show » 187 21.8 No 0
ANK2-023 ENSP00000422888
ENST00000506344
A5XEK0
Show all »
197 22 No 0
ANK2-024 ENSP00000422486
ENST00000514167
A5XEJ9
Show all »
81 8.9 No 0
ANK2-026 ENSP00000264366
ENST00000264366
I6L894
Show all »
Show » 3924 430.3 No 0