PIK3R1

GENE INFORMATION

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Gene name

PIK3R1 (HGNC Symbol)

Synonyms

GRB1, p85, p85-ALPHA

Description

phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (HGNC Symbol)

Entrez gene summary

Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

Chromosome

5 (Chromosome progress)

Cytoband

q13.1

Chromosome location (bp)

67511548 - 67597649

Ensembl

ENSG00000145675 (version 73.37)

Entrez gene

5295

UniProt

P27986 (UniProt - Evidence at protein level)

neXtProt

NX_P27986

Antibodypedia

PIK3R1 antibodies
 

PROTEIN VIEW

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 « 
 
PIK3R1-001
 
PIK3R1-002
 
PIK3R1-003
 
PIK3R1-004
 
PIK3R1-009
 
PIK3R1-010
 
PIK3R1-011
 
PIK3R1-012
 
PIK3R1-014
 
PIK3R1-015
 
PIK3R1-016
 
PIK3R1-201
 
PIK3R1-202
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PIK3R1-001 ENSP00000428056
ENST00000521381
P27986
Show all »
Show » Show » 724 83.6 No 0
PIK3R1-002 ENSP00000323512
ENST00000320694
P27986
Show all »
Show » Show » 424 50 No 0
PIK3R1-003 ENSP00000338554
ENST00000336483
P27986
Show all »
Show » Show » 454 53.5 No 0
PIK3R1-004 ENSP00000430098
ENST00000523872
P27986
Show all »
Show » Show » 361 42.8 No 0
PIK3R1-009 ENSP00000430126
ENST00000523807
E5RGI8
Show all »
Show » Show » 117 13.3 No 0
PIK3R1-010 ENSP00000429766
ENST00000522084
E5RHI0
Show all »
Show » Show » 102 11.5 No 0
PIK3R1-011 ENSP00000431058
ENST00000521409
E5RJY0
Show all »
Show » Show » 137 16.3 No 0
PIK3R1-012 ENSP00000430424
ENST00000517698
E5RK66
Show all »
Show » 38 4.5 No 0
PIK3R1-014 ENSP00000428566
ENST00000520675
H0YB27
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Show » Show » 132 14.8 No 0
PIK3R1-015 ENSP00000429156
ENST00000519025
H0YBC2
Show all »
Show » Show » 189 22.4 No 0
PIK3R1-016 ENSP00000429277
ENST00000521657
P27986
Show all »
Show » Show » 724 83.6 No 0
PIK3R1-201 ENSP00000274335
ENST00000274335
P27986
Show all »
Show » Show » 724 83.6 No 0
PIK3R1-202 ENSP00000379855
ENST00000396611
P27986
Show all »
Show » Show » 732 84.5 No 0