PAM

GENE INFORMATION

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Gene name

PAM (HGNC Symbol)

Synonyms

PAL, PHM

Description

peptidylglycine alpha-amidating monooxygenase (HGNC Symbol)

Entrez gene summary

This gene encodes a multifunctional protein. It has two enzymatically active domains with catalytic activities - peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL). These catalytic domains work sequentially to catalyze neuroendocrine peptides to active alpha-amidated products. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene but some of their full length sequences are not yet known. [provided by RefSeq, Jul 2008]

Chromosome

5 (Chromosome progress)

Cytoband

q21.1

Chromosome location (bp)

102089685 - 102366809

Ensembl

ENSG00000145730 (version 73.37)

Entrez gene

5066

UniProt

P19021 (UniProt - Evidence at protein level)

neXtProt

NX_P19021

Antibodypedia

PAM antibodies
 

PROTEIN VIEW

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 « 
 
PAM-001
 
PAM-002
 
PAM-003
 
PAM-004
 
PAM-005
 
PAM-006
 
PAM-008
 
PAM-010
 
PAM-012
 
PAM-016
 
PAM-017
 
PAM-018
 
PAM-019
 
PAM-029
 
PAM-201
 
PAM-202
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PAM-001 ENSP00000314638
ENST00000348126
P19021
Show all »
Show » Show » 866 96.3 Yes 1
PAM-002 ENSP00000403461
ENST00000455264
P19021
Show all »
Show » Show » 905 100.8 Yes 0
PAM-003 ENSP00000282992
ENST00000346918
P19021
Show all »
Show » Show » 887 98.8 Yes 0
PAM-004 ENSP00000396493
ENST00000438793
P19021
Show all »
Show » Show » 973 108.3 Yes 1
PAM-005 ENSP00000369125
ENST00000379799
Show » 679 75.6 No 0
PAM-006 ENSP00000302544
ENST00000345721
F8W8D9
Show all »
Show » Show » 175 19.6 Yes 1
PAM-008 ENSP00000424203
ENST00000504691
Show » Show » 250 27.6 No 1
PAM-010 ENSP00000420851
ENST00000512073
D6RDU2
Show all »
Show » 25 2.7 Yes 0
PAM-012 ENSP00000421569
ENST00000505654
D6RF09
Show all »
Show » 29 3.1 Yes 0
PAM-016 ENSP00000426448
ENST00000511839
D6RG20
Show all »
Show » 68 7.5 Yes 0
PAM-017 ENSP00000421823
ENST00000511477
D6RAQ2
Show all »
Show » 42 4.7 Yes 0
PAM-018 ENSP00000423611
ENST00000506006
D6R961
Show all »
Show » Show » 28 3 Yes 0
PAM-019 ENSP00000423763
ENST00000509832
D6RCD5
Show all »
Show » 53 5.9 Yes 0
PAM-029 ENSP00000306100
ENST00000304400
P19021
Show all »
Show » Show » 974 108.4 Yes 1
PAM-201 ENSP00000274392
ENST00000274392
F8WE90
Show all »
Show » Show » 875 97.4 No 1
PAM-202 ENSP00000369113
ENST00000379787
A6NMH0
Show all »
Show » Show » 335 36.7 No 1