EGFR

GENE INFORMATION

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Gene name

EGFR (HGNC Symbol)

Synonyms

ERBB, ERBB1

Description

epidermal growth factor receptor (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Chromosome

7 (Chromosome progress)

Cytoband

p11.2

Chromosome location (bp)

55086714 - 55324313

Ensembl

ENSG00000146648 (version 73.37)

Entrez gene

1956

UniProt

P00533 (UniProt - Evidence at protein level)

neXtProt

NX_P00533

Antibodypedia

EGFR antibodies
 

PROTEIN VIEW

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EGFR-001
 
EGFR-002
 
EGFR-003
 
EGFR-004
 
EGFR-005
 
EGFR-009
 
EGFR-201
 
EGFR-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EGFR-001 ENSP00000275493
ENST00000275493
P00533
Show all »
Show » Show » 1210 134.3 Yes 1
EGFR-002 ENSP00000345973
ENST00000344576
P00533
Show all »
Show » Show » 705 77.3 Yes 0
EGFR-003 ENSP00000342376
ENST00000342916
P00533
Show all »
Show » Show » 628 69.2 Yes 0
EGFR-004 ENSP00000415559
ENST00000455089
Q504U8
Show all »
Show » Show » 1091 120.7 Yes 1
EGFR-005 ENSP00000413843
ENST00000420316
P00533
Show all »
Show » Show » 405 44.7 Yes 0
EGFR-009 ENSP00000413354
ENST00000450046
C9JYS6
Show all »
Show » Show » 128 14.7 No 0
EGFR-201 ENSP00000410031
ENST00000442591
F1JTL6
Show all »
Show » Show » 657 72.4 Yes 0
EGFR-202 ENSP00000395243
ENST00000454757
E9PFD7
Show all »
Show » Show » 1157 128.7 No 1