IGFBP3

GENE INFORMATION

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Gene name

IGFBP3 (HGNC Symbol)

Synonyms

BP-53, IBP3

Description

insulin-like growth factor binding protein 3 (HGNC Symbol)

Entrez gene summary

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

7 (Chromosome progress)

Cytoband

p12.3

Chromosome location (bp)

45951949 - 45961473

Ensembl

ENSG00000146674 (version 73.37)

Entrez gene

3486

UniProt

P17936 (UniProt - Evidence at protein level)

neXtProt

NX_P17936

Antibodypedia

IGFBP3 antibodies
 

PROTEIN VIEW

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IGFBP3-001
 
IGFBP3-008
 
IGFBP3-014
 
IGFBP3-018
 
IGFBP3-019
 
IGFBP3-020
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IGFBP3-001 ENSP00000275521
ENST00000275521
P17936
Show all »
Show » Show » 291 31.7 Yes 0
IGFBP3-008 ENSP00000370476
ENST00000381086
B3KWK7
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Show » 194 21.8 No 0
IGFBP3-014 ENSP00000389668
ENST00000448817
C9JMX4
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Show » 132 14.9 No 0
IGFBP3-018 ENSP00000390298
ENST00000428530
B3KPF0
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143 16.4 No 0
IGFBP3-019 ENSP00000399116
ENST00000417621
B3KPF0
Show all »
153 17.5 No 0
IGFBP3-020 ENSP00000370473
ENST00000381083
P17936
Show all »
Show » Show » 297 32.2 Yes 0