SHROOM2

GENERAL INFORMATION

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Gene name

SHROOM2

Gene description

Shroom family member 2

Protein class

Cytoskeleton related proteins
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Most of the normal cells displayed weak to moderate cytoplasmic immunoreactivity. Thyroid gland, placental trophoblasts, salivary gland, colon and duodenum were strongly stained. Additional nuclear staining was observed in squamous epithelia, testis and Purkinje cells. Fallopian tube, prostate, and post menopausal endometrial glands showed additional membranous positivity. The breast and adipocytes were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA051646
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

SHROOM2 (HGNC Symbol)

Synonyms

APXL

Description

Shroom family member 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene shares significant similarities with the apical protein from Xenopus laevis which is implicated in amiloride-sensitive sodium channel activity. This gene is a strong candidate gene for ocular albinism type 1 syndrome. [provided by RefSeq, Jul 2008]

Chromosome

X

Cytoband

p22.2

Chromosome location (bp)

9786456 - 9949443

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000146950 (version 78.38)

Entrez gene

357

UniProt

Q13796 (UniProt - Evidence at protein level)

neXtProt

NX_Q13796

Antibodypedia

SHROOM2 antibodies


PROTEIN BROWSER

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ENST00000380913
 
ENST00000418909
 
ENST00000452575
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SHROOM2-001 ENSP00000370299
ENST00000380913
Q13796
Show all »
Show » Show » 1616 176.4 No 0
SHROOM2-002 ENSP00000406724
ENST00000452575
C9IZC6
Show all »
Show » Show » 375 42 No 0
SHROOM2-201 ENSP00000415229
ENST00000418909
Show » 450 50.9 No 0