EBP

GENE INFORMATION

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Gene name

EBP (HGNC Symbol)

Synonyms

CDPX2, CHO2, CPX, CPXD

Description

emopamil binding protein (sterol isomerase) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome). [provided by RefSeq, Jul 2008]

Chromosome

X (Chromosome progress)

Cytoband

p11.23

Chromosome location (bp)

48379546 - 48387104

Ensembl

ENSG00000147155 (version 73.37)

Entrez gene

10682

UniProt

Q15125 (UniProt - Evidence at protein level)

neXtProt

NX_Q15125

Antibodypedia

EBP antibodies
 

PROTEIN VIEW

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EBP-001
 
EBP-004
 
EBP-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EBP-001 ENSP00000390031
ENST00000446158
C9JJ78
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Show » Show » 160 18.3 No 3
EBP-004 ENSP00000417052
ENST00000495186
Q15125
Show all »
Show » Show » 230 26.4 No 5
EBP-005 ENSP00000405832
ENST00000414061
C9J719
Show all »
Show » Show » 146 16.7 No 3