HTR2C

GENE INFORMATION

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Gene name

HTR2C (HGNC Symbol)

Synonyms

5-HT2C, HTR1C

Description

5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled (HGNC Symbol)

Entrez gene summary

Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Chromosome

X (Chromosome progress)

Cytoband

q23

Chromosome location (bp)

113818551 - 114144624

Ensembl

ENSG00000147246 (version 73.37)

Entrez gene

3358

UniProt

P28335 (UniProt - Evidence at protein level)

neXtProt

NX_P28335

Antibodypedia

HTR2C antibodies
 

PROTEIN VIEW

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HTR2C-001
 
HTR2C-002
 
HTR2C-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HTR2C-001 ENSP00000361019
ENST00000371951
P28335
Show all »
Show » Show » 458 51.8 Yes 7
HTR2C-002 ENSP00000276198
ENST00000276198
P28335
Show all »
Show » Show » 458 51.8 Yes 7
HTR2C-003 ENSP00000361018
ENST00000371950
P28335
Show all »
Show » Show » 248 28.1 Yes 3