GPC3 protein expression summary - The Human Protein Atlas

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GPC3

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HUMAN PROTEIN ATLAS SUMMARYⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Proteinⁱ Full gene name according to HGNC.	Glypican 3
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GPC3 (DGSX, OCI-5, SDYS, SGB, SGBS, SGBS1)
Tissue specificityⁱ ??The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Tissue enriched (placenta)
Tissue expression clusterⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Placenta - Pregnancy (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Fibroblasts, Syncytiotrophoblasts, Muller glia cells, Cytotrophoblasts, Extravillous trophoblasts)
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Fibroblasts - ECM organization (mainly)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed blood cell samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (naive CD4 T-cell, naive CD8 T-cell)
Brain specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category Read more	Low human brain regional specificity
Cancer prognostic summary	Prognostic marker in stomach cancer (unfavorable)
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular, Membrane (different isoforms)
Subcellular summaryⁱ Describes the main and potential additional location(s) of the encoded protein according to ICC-IF resukt in the Cell Atlas, as well as potential data regarding cell cycle depency (CCD) for the RNA and/or protein expression.	Located in Plasma membrane
Protein function (UniProt)ⁱ Useful information about the protein provided by UniProt.	Cell surface proteoglycan that bears heparan sulfate 1. Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands 2, 3. Positively regulates the non-canonical Wnt signaling pathway (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 4. Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (By similarity). Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (By similarity). Required for coronary vascular development (By similarity). Plays a role in regulating cell movements during gastrulation (By similarity).... show less
Molecular function (UniProt)ⁱ Keywords assigned by UniProt to proteins due to their particular molecular function.	Protease inhibitor
Disease involvementⁱ Disease related keywords assigned by UniProt combined with Cancer-related genes and FDA approved drug targets Read more	Cancer-related genes, Disease variant
Gene summary (Entrez)ⁱ Useful information about the gene from Entrez	Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]... show less

TISSUEⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more

Tissue expression clusterⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Placenta - Pregnancy (mainly)
Tissue specificityⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Tissue enriched (placenta)
Tissue distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many

BRAINⁱ Summary of data presented in the Brain Atlas and a representative image of mRNA expression in the human brain. The image is clickable and will redirect to more Brain Atlas data. The Brain Atlas explores the protein expression in the mammalian brain by visualization and integration of data from three mammalian species (human, pig and mouse). Transcriptomics data combined with affinity-based protein in situ localization down to single cell level is available in a brain-centric sub atlas of the Human Protein Atlas. Read more

Human regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity
Pig regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity
Mouse regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity

SINGLE CELL TYPEⁱ Summary of data presented in the Single cell Type section, with an interactive chart showing the cell type-specific mRNA expression. The chart is clickable and will redirect to more Cell Type data. This section contains information about single cell type RNA expression based on scRNAseq of human tissues. The data also covers transcriptomics analysis of human blood and cultured cell lines. Read more

Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Fibroblasts - ECM organization (mainly)
Cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Fibroblasts, Syncytiotrophoblasts, Muller glia cells, Cytotrophoblasts, Extravillous trophoblasts)

TISSUE CELL TYPEⁱ

Fibroblasts

Classificationⁱ

Core cell type enriched

PATHOLOGYⁱ Summary of data presented in the Pathology section, with representative images of protein expression in cancer (left) and correlation between mRNA expression and patient survival (right). Images are clickable and redirect to pages with more Pathology data. This section contains mRNA and protein expression data from 17 different forms of human cancer, as well as correlation analysis of mRNA expression and patient survival. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more
Stomach cancer p<0.001
Prognostic summary	Prognostic marker in stomach cancer (unfavorable)
Cancer specificityⁱ Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected. Read more	Cancer enriched (liver cancer)
Cancer distributionⁱ Distribution of RNA expression in 17 cancer types is categorized as either detected in single, detected in some, detected in many, detected in all, or not detected. Read more	Detected in all

IMMUNE CELLⁱ Summary of data presented in the Immune Cell section and a representative image of mRNA expression in immune cells in the blood. The image is clickable and will redirect to more immune cell related data. The Immune Cell section contains information regarding single cell type mRNA expression profiles of protein-coding genes in various immune cells in the blood, e.g. B-cells and granulocytes. Read more

Immune cell expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	T-cells - Unknown function (mainly)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (naive CD4 T-cell, naive CD8 T-cell)

BLOOD PROTEINⁱ Summary of data presented in the Blood proteins section and a representative image of the concentration in plasma and related function for the protein in plasma. The image is clickable and will redirect to more data. The Blood proteins section contains plasma levels of proteins detected in human blood and an analysis of the human secretome (including annotation of the genes predicted to be actively secreted to human blood) is also presented. Read more
Detected in blood by immunoassayⁱ The blood-based immunoassay category applies to actively secreted proteins and is based on plasma or serum protein concentrations established with enzyme-linked immunosorbent assays, compiled from a literature search. The categories include: detected and not detected, where detection refers to a concentration found in the literature search. Read more	No (not applicable)
Detected in blood by mass spectrometryⁱ Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics data set obtained from the PeptideAtlas.	Yes
Detected in blood by proximity extension assayⁱ Detection or not of the gene in blood, based on proximity extension assays (Olink) for a longitudinal wellness study covering 76 individuals with three visits during two years. Read more	No

SUBCELLULARⁱ Summary of data presented in the Cell Atlas and a representative image of subcellular localization. The Cell Atlas provides RNA expression data derived from RNA sequencing of a large panel of cell lines and protein localization data derived from antibody-based profiling by immunofluorescence confocal microscopy, using a subset of cell lines selected based on RNA expression. Read more

Main locationⁱ Main subcellular location(s) and reliability score(s) for the encoded protein(s) in human cells. The main location(s) may be characterized by presence in all tested cell lines and/or ihigher staining intensity compared to the potential additional location(s). If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively. Read more	Localized to the Plasma membrane

CELL LINEⁱ Summary of data presented in the Cell Line section and a representative image of mRNA expression across different human cell lines. The image is clickable and will redirect to more cell line data. This section contains information regarding mRNA expression profiles of human protein-coding genes for a large variety of cell lines. Read more

Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Hep G2 - Hepatocyte cell processes (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Group enriched (HAP1, Hep G2)
Cell type distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many

METABOLIC

Metabolic info	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	GPC3 (HGNC Symbol)
Synonyms	DGSX, OCI-5, SDYS, SGB, SGBS, SGBS1
Description	Glypican 3 (HGNC Symbol)
Chromosome	X
Cytoband	q26.2
Chromosome location (bp)	133535745 - 133985594
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4
Protein evidence	Evidence at protein level (all genes)
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Human disease related genes
Ensembl	ENSG00000147257 (version 103.38)
Entrez gene	2719
UniProt	P51654 (UniProt - Evidence at protein level)
neXtProt	NX_P51654
Antibodypedia	GPC3 antibodies

PROTEIN BROWSERⁱ

GPC3-201

GPC3-202

GPC3-203

GPC3-204

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPC3-201 ENSP00000359854 ENST00000370818	P51654 [Direct mapping] Glypican-3 Glypican-3 alpha subunit Glypican-3 beta subunit I6QTG3 [Target identity:100%; Query identity:100%] Glypican-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001523 [retinoid metabolic process] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005788 [endoplasmic reticulum lumen] GO:0005796 [Golgi lumen] GO:0005886 [plasma membrane] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0006027 [glycosaminoglycan catabolic process] GO:0009653 [anatomical structure morphogenesis] GO:0009966 [regulation of signal transduction] GO:0009986 [cell surface] GO:0010466 [negative regulation of peptidase activity] GO:0016020 [membrane] GO:0016477 [cell migration] GO:0030414 [peptidase inhibitor activity] GO:0031225 [anchored component of membrane] GO:0031226 [intrinsic component of plasma membrane] GO:0042074 [cell migration involved in gastrulation] GO:0043202 [lysosomal lumen] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045732 [positive regulation of protein catabolic process] GO:0045807 [positive regulation of endocytosis] GO:0045879 [negative regulation of smoothened signaling pathway] GO:0046658 [anchored component of plasma membrane] GO:0060422 [peptidyl-dipeptidase inhibitor activity] GO:0060828 [regulation of canonical Wnt signaling pathway] GO:0060976 [coronary vasculature development] GO:0062023 [collagen-containing extracellular matrix] GO:0072111 [cell proliferation involved in kidney development] GO:0072138 [mesenchymal cell proliferation involved in ureteric bud development] GO:0072180 [mesonephric duct morphogenesis] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:1905475 [regulation of protein localization to membrane] GO:2000050 [regulation of non-canonical Wnt signaling pathway] Show all	580 aa 65.6 kDa	Yes	1
GPC3-202 ENSP00000377836 ENST00000394299	P51654 [Direct mapping] Glypican-3 Glypican-3 alpha subunit Glypican-3 beta subunit Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001523 [retinoid metabolic process] GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0001822 [kidney development] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005764 [lysosome] GO:0005788 [endoplasmic reticulum lumen] GO:0005796 [Golgi lumen] GO:0005886 [plasma membrane] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0006027 [glycosaminoglycan catabolic process] GO:0008285 [negative regulation of cell population proliferation] GO:0009617 [response to bacterium] GO:0009653 [anatomical structure morphogenesis] GO:0009887 [animal organ morphogenesis] GO:0009948 [anterior/posterior axis specification] GO:0009966 [regulation of signal transduction] GO:0009986 [cell surface] GO:0010171 [body morphogenesis] GO:0010466 [negative regulation of peptidase activity] GO:0016020 [membrane] GO:0016477 [cell migration] GO:0030282 [bone mineralization] GO:0030316 [osteoclast differentiation] GO:0030324 [lung development] GO:0030414 [peptidase inhibitor activity] GO:0030513 [positive regulation of BMP signaling pathway] GO:0031225 [anchored component of membrane] GO:0031226 [intrinsic component of plasma membrane] GO:0035116 [embryonic hindlimb morphogenesis] GO:0040008 [regulation of growth] GO:0042074 [cell migration involved in gastrulation] GO:0043202 [lysosomal lumen] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045732 [positive regulation of protein catabolic process] GO:0045807 [positive regulation of endocytosis] GO:0045879 [negative regulation of smoothened signaling pathway] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0045926 [negative regulation of growth] GO:0046326 [positive regulation of glucose import] GO:0046658 [anchored component of plasma membrane] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0060422 [peptidyl-dipeptidase inhibitor activity] GO:0060828 [regulation of canonical Wnt signaling pathway] GO:0060976 [coronary vasculature development] GO:0062023 [collagen-containing extracellular matrix] GO:0072111 [cell proliferation involved in kidney development] GO:0072138 [mesenchymal cell proliferation involved in ureteric bud development] GO:0072180 [mesonephric duct morphogenesis] GO:0072203 [cell proliferation involved in metanephros development] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:1905475 [regulation of protein localization to membrane] GO:2000050 [regulation of non-canonical Wnt signaling pathway] GO:2000096 [positive regulation of Wnt signaling pathway, planar cell polarity pathway] Show all	603 aa 68.4 kDa	Yes	1
GPC3-203 ENSP00000385307 ENST00000406757	H0Y3U6 [Direct mapping] Glypican-3 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0009966 [regulation of signal transduction] GO:0016020 [membrane] GO:0031225 [anchored component of membrane] GO:0046658 [anchored component of plasma membrane] GO:0062023 [collagen-containing extracellular matrix] Show all	256 aa 29 kDa	No	0
GPC3-204 ENSP00000486325 ENST00000631057	P51654 [Direct mapping] Glypican-3 Glypican-3 alpha subunit Glypican-3 beta subunit Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001523 [retinoid metabolic process] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005788 [endoplasmic reticulum lumen] GO:0005796 [Golgi lumen] GO:0005886 [plasma membrane] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0006027 [glycosaminoglycan catabolic process] GO:0009653 [anatomical structure morphogenesis] GO:0009966 [regulation of signal transduction] GO:0009986 [cell surface] GO:0010466 [negative regulation of peptidase activity] GO:0016020 [membrane] GO:0016477 [cell migration] GO:0030414 [peptidase inhibitor activity] GO:0031225 [anchored component of membrane] GO:0031226 [intrinsic component of plasma membrane] GO:0042074 [cell migration involved in gastrulation] GO:0043202 [lysosomal lumen] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045732 [positive regulation of protein catabolic process] GO:0045807 [positive regulation of endocytosis] GO:0045879 [negative regulation of smoothened signaling pathway] GO:0046658 [anchored component of plasma membrane] GO:0060422 [peptidyl-dipeptidase inhibitor activity] GO:0060828 [regulation of canonical Wnt signaling pathway] GO:0060976 [coronary vasculature development] GO:0062023 [collagen-containing extracellular matrix] GO:0072111 [cell proliferation involved in kidney development] GO:0072138 [mesenchymal cell proliferation involved in ureteric bud development] GO:0072180 [mesonephric duct morphogenesis] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:1905475 [regulation of protein localization to membrane] GO:2000050 [regulation of non-canonical Wnt signaling pathway] Show all	526 aa 59.5 kDa	Yes	1

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