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GENE:
GPC3
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INFO
GENE/PROTEIN
ANTIBODY/ANTIGEN
EXPRESSION
SUBCELLULAR LOCATION
NORMAL TISSUE
CANCER TISSUE
CELL LINE
RNA
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Gene name
Protein class
Chromosome
External id
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Subcellular location (IF)
Organ expression (IH)
Tissue expression (IH)
Cancer expression (IH)
Cell expression (IH)
—
IH validation
IF validation
WB validation
PA validation
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Evidence summary
UniProt evidence
HPA evidence
RNA evidence
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With antibodies
With annotated expression (IH)
With annotated expression (IF)
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Term
Gene name
Class
Kinases
CD markers
Blood group antigen proteins
Transporters
Ribosomal proteins
Peptidases
Candidate cancer biomarkers
G-protein coupled receptors
Plasma proteins
Candidate cardiovascular disease genes
Transcription factors
Enzymes
SH2-domain containing proteins
SH3-domain containing proteins
Mutated genes in cancer
Voltage-gated ion channels
Potential transmembrane proteins
Potentially secreted proteins
Mapped to UniProt SWISS-PROT
Subclass
Chromosome
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
MT
Unmapped
X
Y
External id
Location
Nucleus
Nucleoli
Nucleus but not nucleoli
Nuclear membrane
Plasma membrane
Cytoplasm
Mitochondria
Endoplasmic reticulum
Golgi apparatus
Vesicles
Microtubule organizing center
Cytoskeleton
Cytoskeleton (Actin filaments)
Cytoskeleton (Intermediate filaments)
Cytoskeleton (Microtubules)
Cytoskeleton (Cytokinetic bridge)
Centrosome
Extracellular matrix
Focal Adhesions
Cell Junctions
Aggresome
Organ
Any
Central nervous system (Brain)
Blood and immune system (Hematopoietic)
Liver and pancreas
Digestive tract (GI-tract)
Respiratory system (Lung)
Cardiovascular system (Heart and blood vessels)
Breast and female reproductive system (Female tissues)
Placenta
Male reproductive system (Male tissues)
Urinary tract (Kidney and bladder)
Skin and soft tissues
Endocrine glands
Fraction
>
<
=
tissues
0%
5%
10%
15%
20%
25%
30%
35%
40%
45%
50%
55%
60%
65%
70%
75%
80%
85%
90%
95%
100%
Expression
Negative
Weak
Moderate
Strong
Tissue
Any
Adrenal gland
Appendix
Bone marrow
Breast
Bronchus
Cerebellum
Cerebral cortex
Cervix, uterine
Colon
Duodenum
Epididymis
Esophagus
Fallopian tube
Gallbladder
Heart muscle
Hippocampus
Kidney
Lateral ventricle
Liver
Lung
Lymph node
Nasopharynx
Oral mucosa
Ovary
Pancreas
Parathyroid gland
Placenta
Prostate
Rectum
Salivary gland
Seminal vesicle
Skeletal muscle
Skin
Small intestine
Smooth muscle
Soft tissue 1
Soft tissue 2
Spleen
Stomach, lower
Stomach, upper
Testis
Thyroid gland
Tonsil
Urinary bladder
Uterus, post-menopause
Uterus, pre-menopause
Vagina
Vulva/anal skin
Cell type
Expression
Negative
Weak
Moderate
Strong
Tissue
Any
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer
Fraction
>
<
=
patients
0%
5%
10%
15%
20%
25%
30%
35%
40%
45%
50%
55%
60%
65%
70%
75%
80%
85%
90%
95%
100%
Expression
Negative
Weak
Moderate
Strong
Cell
Any
A-431
A-549
AN3-CA
BEWO
CACO-2
CAPAN-2
D341 Med
Daudi
EFO-21
HaCaT
HDLM-2
HEK 293
HEL
HeLa
Hep-G2
HL-60
HMC-1
HTh 83
K-562
Karpas-707
KM3
Leukemia, AML
Leukemia, B-ALL
Leukemia, B-CLL
Leukemia, CML
Leukemia, T-ALL
LP-1
MCF-7
MOLT-4
NB-4
NTERA-2
PBMC
PC-3
RH-30
RPMI-8226
RT-4
SCLC-21H
SH-SY5Y
SiHa
SK-BR-3
SK-MEL-30
THP-1
TIME
U-138 MG
U-2 OS
U-2197
U-251 MG
U-266/70
U-266/84
U-698
U-87 MG
U-937
WM-115
Expression
Negative
Weak
Moderate
Strong
Validation
Supportive
Uncertain
Non-supportive
Validation
Supportive
Uncertain
Non-supportive
Validation
Supportive
Uncertain
Non-supportive
Validation
Supportive
Uncertain
Non-supportive
Category
High
Medium
Low
Only RNA
None
Score
Class 1
Class 2
Class 3-5
Score
High
Medium
Low
Very low
Score
High
Medium
Low
Not detected
Antibodies
Yes
No
Annotated expression
Yes
No
Annotated expression
Yes
No
Column
gene
position
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Tissue malignant melanoma not found!
