GPC3

GENE INFORMATION

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Gene name

GPC3 (HGNC Symbol)

Synonyms

DGSX, OCI-5, SDYS, SGB, SGBS, SGBS1

Description

glypican 3 (HGNC Symbol)

Entrez gene summary

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

Chromosome

X (Chromosome progress)

Cytoband

q26.2

Chromosome location (bp)

132669773 - 133119922

Ensembl

ENSG00000147257 (version 73.37)

Entrez gene

2719

UniProt

P51654 (UniProt - Evidence at protein level)

neXtProt

NX_P51654

Antibodypedia

GPC3 antibodies
 

PROTEIN VIEW

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GPC3-001
 
GPC3-002
 
GPC3-201
 
GPC3-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GPC3-001 ENSP00000359854
ENST00000370818
P51654
Show all »
Show » Show » 580 65.6 Yes 1
GPC3-002 ENSP00000385307
ENST00000406757
Show » Show » 256 29 No 0
GPC3-201 ENSP00000377836
ENST00000394299
P51654
Show all »
Show » Show » 603 68.4 Yes 1
GPC3-202 ENSP00000444222
ENST00000543339
P51654
Show all »
Show » Show » 526 59.5 Yes 1