ATP6V1B2

GENE INFORMATION

? »

Gene name

ATP6V1B2 (HGNC Symbol)

Synonyms

ATP6B2, HO57, VATB, Vma2, VPP3

Description

ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 (HGNC Symbol)

Entrez gene summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq, Jul 2008]

Chromosome

8 (Chromosome progress)

Cytoband

p21.3

Chromosome location (bp)

20054878 - 20084330

Ensembl

ENSG00000147416 (version 73.37)

Entrez gene

526

UniProt

P21281 (UniProt - Evidence at protein level)

neXtProt

NX_P21281

Antibodypedia

ATP6V1B2 antibodies
 

PROTEIN VIEW

? »
 
 
 
ATP6V1B2-001
 
ATP6V1B2-004
 
ATP6V1B2-005
 
ATP6V1B2-006
 
ATP6V1B2-007
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP6V1B2-001 ENSP00000276390
ENST00000276390
P21281
Show all »
Show » Show » 511 56.5 No 0
ATP6V1B2-004 ENSP00000428069
ENST00000520830
56 5.7 No 0
ATP6V1B2-005 ENSP00000430682
ENST00000519667
Show » 199 21 No 0
ATP6V1B2-006 ENSP00000430154
ENST00000523478
E5RGH6
Show all »
66 6.9 No 0
ATP6V1B2-007 ENSP00000430866
ENST00000521442
Show » 49 5.4 No 0