VLDLR

GENERAL INFORMATION

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Gene name

VLDLR

Gene description

Very low density lipoprotein receptor

Protein class

Disease related genes
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most of the normal tissues showed weak to moderate cytoplasmic positivity. Gastrointestinal tract, exocrine pancreas, distal renal tubules, decidual cells and Purkinje cells displayed strong cytoplasmic immunoreactivity. Lung, liver, glial cells and lymphoid tissues were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB032462
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

VLDLR (HGNC Symbol)

Synonyms

CARMQ1, CHRMQ1, VLDLRCH

Description

Very low density lipoprotein receptor (HGNC Symbol)

Entrez gene summary

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009]

Chromosome

9

Cytoband

p24.2

Chromosome location (bp)

2621834 - 2660053

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000147852 (version 78.38)

Entrez gene

7436

UniProt

P98155 (UniProt - Evidence at protein level)

neXtProt

NX_P98155

Antibodypedia

VLDLR antibodies


PROTEIN BROWSER

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ENST00000382096
 
ENST00000382099
 
ENST00000382100
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

VLDLR-001 ENSP00000371532
ENST00000382100
P98155
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Show » Show » 873 96.1 Yes 1
VLDLR-002 ENSP00000371531
ENST00000382099
P98155
Show all »
Show » Show » 845 93.4 Yes 1
VLDLR-005 ENSP00000371528
ENST00000382096
Q5VVF8
Show all »
Show » Show » 173 18.7 Yes 0