CDKN2A

GENE INFORMATION

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Gene name

CDKN2A (HGNC Symbol)

Synonyms

ARF, CDK4I, CDKN2, CMM2, INK4, INK4a, MLM, MTS1, p14, p16, p16INK4a, p19, p19Arf

Description

cyclin-dependent kinase inhibitor 2A (HGNC Symbol)

Entrez gene summary

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]

Chromosome

9 (Chromosome progress)

Cytoband

p21.3

Chromosome location (bp)

21967751 - 21995300

Ensembl

ENSG00000147889 (version 73.37)

Entrez gene

1029

UniProt

P42771 (UniProt - Evidence at protein level), Q8N726 (UniProt - Evidence at protein level)

neXtProt

NX_P42771, NX_Q8N726

Antibodypedia

CDKN2A antibodies
 

PROTEIN VIEW

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CDKN2A-001
 
CDKN2A-003
 
CDKN2A-004
 
CDKN2A-005
 
CDKN2A-006
 
CDKN2A-008
 
CDKN2A-009
 
CDKN2A-010
 
CDKN2A-013
 
CDKN2A-014
 
CDKN2A-015
 
CDKN2A-201
 
CDKN2A-202
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDKN2A-001 ENSP00000307101
ENST00000304494
P42771
Show all »
Show » Show » 156 16.5 No 0
CDKN2A-003 ENSP00000369496
ENST00000380151
G3XAG3
Show all »
Show » Show » 116 12.1 No 0
CDKN2A-004 ENSP00000462950
ENST00000579755
Q8N726
Show all »
Show » Show » 132 13.9 No 0
CDKN2A-005 ENSP00000464952
ENST00000494262
P42771
Show all »
Show » Show » 105 11.2 Yes 0
CDKN2A-006 ENSP00000467857
ENST00000498628
P42771
Show all »
Show » Show » 105 11.2 Yes 0
CDKN2A-008 ENSP00000466887
ENST00000479692
K7ENC6
Show all »
Show » 121 12.7 Yes 0
CDKN2A-009 ENSP00000418915
ENST00000498124
P42771
Show all »
Show » Show » 167 17.9 No 0
CDKN2A-010 ENSP00000468510
ENST00000497750
K7ES20
Show all »
Show » 104 11.1 Yes 0
CDKN2A-013 ENSP00000432664
ENST00000530628
Q8N726
Show all »
Show » Show » 132 13.9 No 0
CDKN2A-014 ENSP00000464202
ENST00000579122
J3QRG6
Show all »
Show » 138 15 No 0
CDKN2A-015 ENSP00000467390
ENST00000578845
P42771
Show all »
Show » Show » 105 11.2 Yes 0
CDKN2A-201 ENSP00000355153
ENST00000361570
Q8N726
Show all »
Show » Show » 173 18 No 0
CDKN2A-202 ENSP00000394932
ENST00000446177
P42771
Show all »
Show » Show » 167 17.9 No 0