The Human Protein Atlas

Gene name

NTRK2 (HGNC Symbol)

Synonyms

TRKB

Description

neurotrophic tyrosine kinase, receptor, type 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

9 (Chromosome progress)

Cytoband

q21.33

Chromosome location (bp)

87283466 - 87638505

Ensembl

ENSG00000148053 (version 69.37)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NTRK2-001

ENSP00000314586
ENST00000323115

Q16620
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Q16620 [Direct mapping]
BDNF/NT-3 growth factors receptor
Q548C2 [Target identity:100%; Query identity:100%]
Tyrosine-protein kinase receptor
Q8WXJ4 [Target identity:8%; Query identity:100%]
Neurotrophin receptor tyrosine kinase type 2

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Kinases
   Tyr protein kinases
Candidate cancer biomarkers
Enzymes
   Transferases
Potential transmembrane proteins
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   1TM proteins predicted by MDM
Potentially secreted proteins
   Secreted proteins predicted by MDSP
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Mapped to UniProt SWISS-PROT
   UniProt - Evidence at protein level

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GO:0001764 [neuron migration]
GO:0005524 [ATP binding]
GO:0005887 [integral to plasma membrane]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007612 [learning]
GO:0008284 [positive regulation of cell proliferation]
GO:0010008 [endosome membrane]
GO:0010628 [positive regulation of gene expression]
GO:0010976 [positive regulation of neuron projection development]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase cascade]
GO:0021954 [central nervous system neuron development]
GO:0021987 [cerebral cortex development]
GO:0030182 [neuron differentiation]
GO:0031547 [brain-derived neurotrophic factor receptor signaling pathway]
GO:0032314 [regulation of Rac GTPase activity]
GO:0042803 [protein homodimerization activity]
GO:0043121 [neurotrophin binding]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0046777 [protein autophosphorylation]
GO:0048011 [nerve growth factor receptor signaling pathway]
GO:0048403 [brain-derived neurotrophic factor binding]
GO:0050772 [positive regulation of axonogenesis]
GO:0060175 [brain-derived neurotrophic factor-activated receptor activity]

822

Yes

NTRK2-002

ENSP00000365381
ENST00000376208

Q16620
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Q16620 [Direct mapping]
BDNF/NT-3 growth factors receptor
Q8WXJ8 [Target identity:19%; Query identity:100%]
Neurotrophin receptor tyrosine kinase type 2 truncated isoform
Q8WXJ4 [Target identity:13%; Query identity:100%]
Neurotrophin receptor tyrosine kinase type 2

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537

59.2

Yes

NTRK2-003

ENSP00000306167
ENST00000304053

Q16620
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Q16620 [Direct mapping]
BDNF/NT-3 growth factors receptor
Q8WXJ4 [Target identity:12%; Query identity:100%]
Neurotrophin receptor tyrosine kinase type 2

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553

Yes

NTRK2-004

ENSP00000277120
ENST00000277120

Q16620
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Q16620 [Direct mapping]
BDNF/NT-3 growth factors receptor
Q8WXJ4 [Target identity:8%; Query identity:100%]
Neurotrophin receptor tyrosine kinase type 2

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838

93.8

Yes

NTRK2-005

ENSP00000352906
ENST00000359847

Q16620
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Q16620 [Direct mapping]
BDNF/NT-3 growth factors receptor
Q5VWE5 [Target identity:100%; Query identity:100%]
Neurotrophic tyrosine kinase, receptor, type 2; Neurotrophic tyrosine kinase, receptor, type 2, isoform CRA_a; cDNA FLJ76753, highly similar to Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant b, mRNA
Q8WXJ4 [Target identity:14%; Query identity:100%]
Neurotrophin receptor tyrosine kinase type 2

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477

53.1

Yes

NTRK2-201

ENSP00000365386
ENST00000376213

Q16620
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822

Yes

NTRK2-202

ENSP00000365387
ENST00000376214

Q16620
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Q16620 [Direct mapping]
BDNF/NT-3 growth factors receptor
Q8WXJ4 [Target identity:8%; Query identity:100%]
Neurotrophin receptor tyrosine kinase type 2

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GO:0000139 [Golgi membrane]
GO:0001570 [vasculogenesis]
GO:0001764 [neuron migration]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005030 [neurotrophin receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral to plasma membrane]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007612 [learning]
GO:0007631 [feeding behavior]
GO:0008284 [positive regulation of cell proliferation]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010628 [positive regulation of gene expression]
GO:0010976 [positive regulation of neuron projection development]
GO:0014047 [glutamate secretion]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase cascade]
GO:0014069 [postsynaptic density]
GO:0019222 [regulation of metabolic process]
GO:0021954 [central nervous system neuron development]
GO:0021987 [cerebral cortex development]
GO:0030182 [neuron differentiation]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0031547 [brain-derived neurotrophic factor receptor signaling pathway]
GO:0032314 [regulation of Rac GTPase activity]
GO:0035584 [calcium-mediated signaling using intracellular calcium source]
GO:0042490 [mechanoreceptor differentiation]
GO:0042803 [protein homodimerization activity]
GO:0043025 [neuronal cell body]
GO:0043121 [neurotrophin binding]
GO:0043195 [terminal button]
GO:0043197 [dendritic spine]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043679 [axon terminus]
GO:0046548 [retinal rod cell development]
GO:0046777 [protein autophosphorylation]
GO:0046928 [regulation of neurotransmitter secretion]
GO:0048011 [nerve growth factor receptor signaling pathway]
GO:0048403 [brain-derived neurotrophic factor binding]
GO:0048709 [oligodendrocyte differentiation]
GO:0048786 [presynaptic active zone]
GO:0048935 [peripheral nervous system neuron development]
GO:0050772 [positive regulation of axonogenesis]
GO:0050773 [regulation of dendrite development]
GO:0051896 [regulation of protein kinase B signaling cascade]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0060076 [excitatory synapse]
GO:0060175 [brain-derived neurotrophic factor-activated receptor activity]
GO:0060291 [long-term synaptic potentiation]
GO:2000811 [negative regulation of anoikis]

838

93.8

Yes

NTRK2-203

ENSP00000379207
ENST00000395866

Q16620
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Q16620 [Direct mapping]
BDNF/NT-3 growth factors receptor

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Kinases
   Tyr protein kinases
Candidate cancer biomarkers
Enzymes
   Transferases
Potential transmembrane proteins
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   1TM proteins predicted by MDM
Mapped to UniProt SWISS-PROT
   UniProt - Evidence at protein level

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321

35.3

NTRK2-204

ENSP00000379221
ENST00000395882

Q16620
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477

53.1

Yes

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.