AUH

GENE INFORMATION

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Gene name

AUH

Synonyms

Description

AU RNA binding protein/enoyl-CoA hydratase (HGNC Symbol)

Entrez gene summary

The methylglutaconyl-CoA hydratase, mitochondrial protein binds to the AU-rich element (ARE), a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92% identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb, and translated as a 40-kDa precursor protein which is subsequently processed to a 32-kDa mature form. [provided by RefSeq, May 2010]

Chromosome

9 (Chromosome progress)

Cytoband

q22.31

Chromosome location (bp)

93976097 - 94124195

Ensembl

ENSG00000148090 (version 73.37)

Entrez gene

549

UniProt

Q13825 (UniProt - Evidence at protein level)

neXtProt

NX_Q13825

Antibodypedia

AUH antibodies
 

PROTEIN VIEW

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AUH-001
 
AUH-002
 
AUH-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AUH-001 ENSP00000364883
ENST00000375731
Q13825
Show all »
Show » Show » 339 35.6 Yes 0
AUH-002 ENSP00000307334
ENST00000303617
Q13825
Show all »
Show » Show » 310 32.5 Yes 0
AUH-201 ENSP00000402026
ENST00000422391
B4DYI6
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Show » Show » 255 26.3 Yes 0