ALAD

GENERAL INFORMATION

? »

Gene name

ALAD

Gene description

Aminolevulinate dehydratase

Protein class

Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in most normal cells. Distinct expression in gastric mucosa, renal tubules, leydig cells, salivary and adrenal glands.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA021023 , HPA022124
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

? »

Gene name

ALAD (HGNC Symbol)

Synonyms

ALADH, PBGS

Description

Aminolevulinate dehydratase (HGNC Symbol)

Entrez gene summary

The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

q32

Chromosome location (bp)

113386317 - 113401333

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000148218 (version 78.38)

Entrez gene

210

UniProt

P13716 (UniProt - Evidence at protein level)

neXtProt

NX_P13716

Antibodypedia

ALAD antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000409155
 
ENST00000445750
 
ENST00000448137
 
ENST00000452726
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ALAD-001 ENSP00000386284
ENST00000409155
P13716
Show all »
Show » Show » 330 36.3 No 0
ALAD-004 ENSP00000392748
ENST00000448137
B7ZBK6
Show all »
Show » Show » 120 13.3 No 0
ALAD-007 ENSP00000415737
ENST00000452726
B7ZBK7
Show all »
Show » Show » 59 6.5 No 0
ALAD-008 ENSP00000398438
ENST00000445750
Show » 14 1.5 No 0