ALAD

GENE INFORMATION

? »

Gene name

ALAD (HGNC Symbol)

Synonyms

ALADH, PBGS

Description

aminolevulinate dehydratase (HGNC Symbol)

Entrez gene summary

The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. [provided by RefSeq, Jul 2008]

Chromosome

9 (Chromosome progress)

Cytoband

q32

Chromosome location (bp)

116148597 - 116163613

Ensembl

ENSG00000148218 (version 73.37)

Entrez gene

210

UniProt

P13716 (UniProt - Evidence at protein level)

neXtProt

NX_P13716

Antibodypedia

ALAD antibodies
 

PROTEIN VIEW

? »
 
 
 
ALAD-001
 
ALAD-004
 
ALAD-007
 
ALAD-008
 
ALAD-201
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ALAD-001 ENSP00000386284
ENST00000409155
P13716
Show all »
Show » Show » 330 36.3 No 0
ALAD-004 ENSP00000392748
ENST00000448137
B7ZBK6
Show all »
Show » 120 13.3 No 0
ALAD-007 ENSP00000415737
ENST00000452726
B7ZBK7
Show all »
Show » 59 6.5 No 0
ALAD-008 ENSP00000398438
ENST00000445750
14 1.5 No 0
ALAD-201 ENSP00000277315
ENST00000277315
B7Z3I9
Show all »
Show » 313 34.5 No 0