PTGES

GENE INFORMATION

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Gene name

PTGES (HGNC Symbol)

Synonyms

MGST-IV, MGST1-L1, MGST1L1, PIG12, TP53I12

Description

prostaglandin E synthase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]

Chromosome

9 (Chromosome progress)

Cytoband

q34.11

Chromosome location (bp)

132500610 - 132515326

Ensembl

ENSG00000148344 (version 73.37)

Entrez gene

9536

UniProt

O14684 (UniProt - Evidence at protein level)

neXtProt

NX_O14684

Antibodypedia

PTGES antibodies
 

PROTEIN VIEW

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PTGES-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTGES-001 ENSP00000342385
ENST00000340607
O14684
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