A1CF

GENE INFORMATION

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Gene name

A1CF (HGNC Symbol)

Synonyms

ACF, ACF64, ACF65, APOBEC1CF, ASP

Description

APOBEC1 complementation factor (HGNC Symbol)

Entrez gene summary

Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Chromosome

10 (Chromosome progress)

Cytoband

q11.23

Chromosome location (bp)

52566322 - 52645435

Ensembl

ENSG00000148584 (version 73.37)

Entrez gene

29974

UniProt

Q9NQ94 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NQ94

Antibodypedia

A1CF antibodies
 

PROTEIN VIEW

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A1CF-001
 
A1CF-002
 
A1CF-003
 
A1CF-004
 
A1CF-006
 
A1CF-201
 
A1CF-202
 
A1CF-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

A1CF-001 ENSP00000363113
ENST00000374001
Q9NQ94
Show all »
Show » 586 64.3 No 0
A1CF-002 ENSP00000363105
ENST00000373993
Q9NQ94
Show all »
Show » 594 65.2 No 0
A1CF-003 ENSP00000397953
ENST00000414883
Q5T0W7
Show all »
Show » 201 22.5 No 0
A1CF-004 ENSP00000363109
ENST00000373997
Q9NQ94
Show all »
Show » 586 64.3 No 0
A1CF-006 ENSP00000363107
ENST00000373995
Q9NQ94
Show all »
Show » 594 65 No 0
A1CF-201 ENSP00000282641
ENST00000282641
Q9NQ94
Show all »
Show » 594 65.2 No 0
A1CF-202 ENSP00000378868
ENST00000395489
F8W9F8
Show all »
Show » 587 64.5 No 0
A1CF-203 ENSP00000378873
ENST00000395495
Q9NQ94
Show all »
Show » 539 58.9 No 0