RGR

GENE INFORMATION

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Gene name

RGR (HGNC Symbol)

Synonyms

RP44

Description

retinal G protein coupled receptor (HGNC Symbol)

Entrez gene summary

This gene encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

10 (Chromosome progress)

Cytoband

q23.1

Chromosome location (bp)

86004809 - 86019716

Ensembl

ENSG00000148604 (version 73.37)

Entrez gene

5995

UniProt

P47804 (UniProt - Evidence at protein level)

neXtProt

NX_P47804

Antibodypedia

RGR antibodies
 

PROTEIN VIEW

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RGR-001
 
RGR-002
 
RGR-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RGR-001 ENSP00000352427
ENST00000359452
P47804
Show all »
Show » Show » 295 32.4 No 7
RGR-002 ENSP00000361164
ENST00000372092
Q96HT6
Show all »
120 12.8 No 0
RGR-201 ENSP00000350823
ENST00000358110
P47804
Show all »
Show » Show » 253 27.7 No 5