GLUD1

GENE INFORMATION

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Gene name

GLUD1 (HGNC Symbol)

Synonyms

GDH, GLUD

Description

glutamate dehydrogenase 1 (HGNC Symbol)

Entrez gene summary

This gene encodes glutamate dehydrogenase protein; a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid induced insulin secretion and activating mutations in this gene are a common cause of congenital hyperinsulinism. This enzyme is allosterically activated by ADP and inhibited by GTP and ATP. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Multiple pseudogenes of this gene are present in humans.[provided by RefSeq, Sep 2009]

Chromosome

10 (Chromosome progress)

Cytoband

q23.2

Chromosome location (bp)

88810243 - 88854623

Ensembl

ENSG00000148672 (version 73.37)

Entrez gene

2746

UniProt

P00367 (UniProt - Evidence at protein level)

neXtProt

NX_P00367

Antibodypedia

GLUD1 antibodies
 

PROTEIN VIEW

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GLUD1-001
 
GLUD1-201
 
GLUD1-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GLUD1-001 ENSP00000277865
ENST00000277865
P00367
Show all »
Show » Show » 558 61.4 Yes 0
GLUD1-201 ENSP00000439291
ENST00000537649
B3KV55
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Show » 391 42.9 No 0
GLUD1-202 ENSP00000444732
ENST00000544149
B4DGN5
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Show » 425 46.6 No 0