CYP17A1

GENE INFORMATION

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Gene name

CYP17A1 (HGNC Symbol)

Synonyms

CPT7, CYP17, P450C17, S17AH

Description

cytochrome P450, family 17, subfamily A, polypeptide 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008]

Chromosome

10 (Chromosome progress)

Cytoband

q24.32

Chromosome location (bp)

104590288 - 104597290

Ensembl

ENSG00000148795 (version 73.37)

Entrez gene

1586

UniProt

P05093 (UniProt - Evidence at protein level)

neXtProt

NX_P05093

Antibodypedia

CYP17A1 antibodies
 

PROTEIN VIEW

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CYP17A1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYP17A1-001 ENSP00000358903
ENST00000369887
P05093
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