ADM

GENE INFORMATION

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Gene name

ADM (HGNC Symbol)

Synonyms

AM

Description

Adrenomedullin (HGNC Symbol)

Entrez gene summary

Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

p15.4

Chromosome location (bp)

10326227 - 10328944

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000148926 (version 75.37)

Entrez gene

133

UniProt

P35318 (UniProt - Evidence at protein level)

neXtProt

NX_P35318

Antibodypedia

ADM antibodies
 

PROTEIN VIEW

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ADM-001
 
ADM-002
 
ADM-003
 
ADM-004
 
ADM-005
 
ADM-006
 
ADM-007
 
ADM-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADM-001 ENSP00000278175
ENST00000278175
P35318
Show all »
Show » Show » 185 20.4 Yes 0
ADM-002 ENSP00000436607
ENST00000528655
P35318
Show all »
Show » Show » 185 20.4 Yes 0
ADM-003 ENSP00000431438
ENST00000534464
E9PL83
Show all »
Show » Show » 138 15.1 No 0
ADM-004 ENSP00000436837
ENST00000530439
E9PQE6
Show all »
Show » Show » 117 12.9 No 0
ADM-005 ENSP00000433062
ENST00000524948
E9PML4
Show all »
Show » Show » 83 9.2 Yes 0
ADM-006 ENSP00000434354
ENST00000526492
E9PQT2
Show all »
Show » Show » 139 15.2 Yes 0
ADM-007 ENSP00000435124
ENST00000525063
P35318
Show all »
Show » Show » 185 20.4 Yes 0
ADM-008 ENSP00000434749
ENST00000528544
E9PML4
Show all »
Show » Show » 83 9.2 Yes 0