MTA2

GENE INFORMATION

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Gene name

MTA2 (HGNC Symbol)

Synonyms

MTA1-L1, MTA1L1

Description

metastasis associated 1 family, member 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]

Chromosome

11 (Chromosome progress)

Cytoband

q12.3

Chromosome location (bp)

62360686 - 62369312

Ensembl

ENSG00000149480 (version 73.37)

Entrez gene

9219

UniProt

O94776 (UniProt - Evidence at protein level)

neXtProt

NX_O94776

Antibodypedia

MTA2 antibodies
 

PROTEIN VIEW

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MTA2-001
 
MTA2-002
 
MTA2-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MTA2-001 ENSP00000278823
ENST00000278823
O94776
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Show » Show » 668 75 No 0
MTA2-002 ENSP00000431346
ENST00000524902
Q68DB1
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Show » Show » 495 55 No 0
MTA2-003 ENSP00000431797
ENST00000527204
Q68DB1
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Show » Show » 495 55 No 0