EI24

GENERAL INFORMATION

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Gene name

EI24

Gene description

Etoposide induced 2.4

Protein class

Cancer-related genes
Disease related genes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

Intracellular,Membrane

Number of transcripts

11
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 2 antibodies.
HPA047165 , HPA051029
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

EI24 (HGNC Symbol)

Synonyms

EPG4, PIG8, TP53I8

Description

Etoposide induced 2.4 (HGNC Symbol)

Entrez gene summary

This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014]

Chromosome

11

Cytoband

q24.2

Chromosome location (bp)

125569216 - 125584687

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000149547 (version 78.38)

Entrez gene

9538

UniProt

O14681 (UniProt - Evidence at protein level)

neXtProt

NX_O14681

Antibodypedia

EI24 antibodies


PROTEIN BROWSER

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ENST00000278903
 
ENST00000524723
 
ENST00000527131
 
ENST00000527235
 
ENST00000527520
 
ENST00000527842
 
ENST00000529812
 
ENST00000534546
 
ENST00000615917
 
ENST00000618552
 
ENST00000620753
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EI24-001 ENSP00000484510
ENST00000620753
O14681
Show all »
Show » Show » 340 39 No 6
EI24-002 ENSP00000278903
ENST00000278903
O14681
Show all »
Show » Show » 340 39 No 6
EI24-003 ENSP00000477849
ENST00000615917
B7ZB74
Show all »
Show » 167 19.1 No 4
EI24-004 ENSP00000480094
ENST00000618552
B7ZB74
Show all »
Show » 167 19.1 No 4
EI24-006 ENSP00000479943
ENST00000534546
O14681
Show all »
Show » Show » 326 37.5 No 6
EI24-007 ENSP00000436130
ENST00000529812
Show » 14 1.6 No 0
EI24-008 ENSP00000433376
ENST00000527131
E9PL33
Show all »
Show » 125 14.6 No 1
EI24-009 ENSP00000435034
ENST00000527842
E9PM05
Show all »
Show » 187 21.6 No 3
EI24-011 ENSP00000435923
ENST00000524723
E9PS58
Show all »
Show » 217 25.1 No 2
EI24-013 ENSP00000435225
ENST00000527520
E9PLB8
Show all »
Show » 91 10.8 No 1
EI24-018 ENSP00000431633
ENST00000527235
E9PM05
Show all »
Show » 262 30.1 No 4