CHEK1

GENE INFORMATION

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Gene name

CHEK1 (HGNC Symbol)

Synonyms

CHK1

Description

checkpoint kinase 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

11 (Chromosome progress)

Cytoband

q24.2

Chromosome location (bp)

125495036 - 125546150

Ensembl

ENSG00000149554 (version 73.37)

Entrez gene

1111

UniProt

O14757 (UniProt - Evidence at protein level)

neXtProt

NX_O14757

Antibodypedia

CHEK1 antibodies
 

PROTEIN VIEW

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 « 
 
CHEK1-001
 
CHEK1-002
 
CHEK1-004
 
CHEK1-006
 
CHEK1-007
 
CHEK1-008
 
CHEK1-009
 
CHEK1-010
 
CHEK1-011
 
CHEK1-013
 
CHEK1-018
 
CHEK1-201
 
CHEK1-202
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CHEK1-001 ENSP00000391090
ENST00000427383
E7EPP6
Show all »
Show » Show » 492 55.5 No 0
CHEK1-002 ENSP00000412504
ENST00000428830
O14757
Show all »
Show » Show » 476 54.4 No 0
CHEK1-004 ENSP00000435371
ENST00000534070
O14757
Show all »
Show » Show » 476 54.4 No 0
CHEK1-006 ENSP00000278916
ENST00000278916
J3KN87
Show all »
Show » Show » 432 49 No 0
CHEK1-007 ENSP00000432890
ENST00000524737
O14757
Show all »
Show » Show » 476 54.4 No 0
CHEK1-008 ENSP00000432470
ENST00000534685
E9PQW7
Show all »
Show » 127 14.4 No 0
CHEK1-009 ENSP00000433103
ENST00000533778
E9PM65
Show all »
Show » 42 4.6 No 0
CHEK1-010 ENSP00000431815
ENST00000526937
E9PJI4
Show all »
Show » 170 19.5 No 0
CHEK1-011 ENSP00000431525
ENST00000527013
E9PKQ3
Show all »
Show » Show » 204 23.3 No 0
CHEK1-013 ENSP00000434646
ENST00000532669
E9PPA5
Show all »
Show » Show » 193 22.3 No 0
CHEK1-018 ENSP00000434141
ENST00000525396
E9PRU7
Show all »
Show » 133 15.2 No 0
CHEK1-201 ENSP00000388648
ENST00000438015
O14757
Show all »
Show » Show » 476 54.4 No 0
CHEK1-202 ENSP00000442317
ENST00000544373
O14757
Show all »
Show » Show » 442 50.4 No 0