MMP3

GENE INFORMATION

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Gene name

MMP3 (HGNC Symbol)

Synonyms

STMY, STMY1

Description

matrix metallopeptidase 3 (stromelysin 1, progelatinase) (HGNC Symbol)

Entrez gene summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

q22.2

Chromosome location (bp)

102706532 - 102714534

Ensembl

ENSG00000149968 (version 73.37)

Entrez gene

4314

UniProt

P08254 (UniProt - Evidence at protein level)

neXtProt

NX_P08254

Antibodypedia

MMP3 antibodies
 

PROTEIN VIEW

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MMP3-001
 
MMP3-002
 
MMP3-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MMP3-001 ENSP00000299855
ENST00000299855
P08254
Show all »
Show » Show » 477 54 Yes 0
MMP3-002 ENSP00000398346
ENST00000434103
99 11.4 No 0
MMP3-003 ENSP00000435255
ENST00000524478
E9PKX2
Show all »
42 4.7 Yes 0