CNKSR2

GENERAL INFORMATION

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Gene name

CNKSR2

Gene description

Connector enhancer of kinase suppressor of Ras 2

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (cerebellum, cerebral cortex, hippocampus)

Protein evidence

Evidence at protein level

Protein localization

RNA data suggests expression in CNS. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Presumed off target binding observed and disregarded. Pending external verification.

Data reliability

Uncertain based on 1 antibody.
HPA001502
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (cerebral cortex)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (cerebellum, cerebral cortex, hippocampus)

Organ

Expression



GENE INFORMATION

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Gene name

CNKSR2 (HGNC Symbol)

Synonyms

CNK2, KIAA0902, KSR2

Description

Connector enhancer of kinase suppressor of Ras 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Chromosome

X

Cytoband

p22.12

Chromosome location (bp)

21374418 - 21654695

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000149970 (version 78.38)

Entrez gene

22866

UniProt

Q8WXI2 (UniProt - Evidence at protein level)

neXtProt

NX_Q8WXI2

Antibodypedia

CNKSR2 antibodies


PROTEIN BROWSER

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ENST00000279451
 
ENST00000379510
 
ENST00000425654
 
ENST00000543067
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CNKSR2-003 ENSP00000368824
ENST00000379510
Q8WXI2
Show all »
Show » Show » 1034 117.5 No 0
CNKSR2-004 ENSP00000279451
ENST00000279451
Q8WXI2
Show all »
Show » Show » 898 101.9 No 0
CNKSR2-201 ENSP00000397906
ENST00000425654
Q8WXI2
Show all »
Show » Show » 1004 113.9 No 0
CNKSR2-202 ENSP00000444633
ENST00000543067
Q8WXI2
Show all »
Show » Show » 849 96.4 No 0