LATS2

GENE INFORMATION

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Gene name

LATS2

Synonyms

Description

large tumor suppressor kinase 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]

Chromosome

13 (Chromosome progress)

Cytoband

q12.11

Chromosome location (bp)

21547171 - 21635686

Ensembl

ENSG00000150457 (version 73.37)

Entrez gene

26524

UniProt

Q9NRM7 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NRM7

Antibodypedia

LATS2 antibodies
 

PROTEIN VIEW

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LATS2-001
 
LATS2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LATS2-001 ENSP00000372035
ENST00000382592
Q9NRM7
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Show » Show » 1088 120.1 No 0
LATS2-201 ENSP00000441817
ENST00000542899
Q9NRM7
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Show » Show » 1088 120.1 No 0